Show simple item record

dc.contributor.authorCannizzo, Elisa
dc.contributor.authorCarulli, Giovanni
dc.contributor.authorDel Vecchio, Luigi
dc.contributor.authorAzzarà, Antonio
dc.contributor.authorGalimberti, Sara
dc.contributor.authorOttaviano, Virginia
dc.contributor.authorPreffer, Frederic Ira
dc.contributor.authorPetrini, Mario
dc.date.accessioned2013-03-29T15:27:24Z
dc.date.issued2011
dc.identifier.citationCannizzo, Elisa, Giovanni Carulli, Luigi Del Vecchio, Antonio Azzarà, Sara Galimberti, Virginia Ottaviano, Frederic Preffer, and Mario Petrini. 2011. Prethymic cytoplasmic CD3 negative acute lymphoblastic leukemia or acute undifferentiated leukemia: a case report. Case Reports in Hematology 2011:230568.en_US
dc.identifier.issn2090-6560en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10473943
dc.description.abstractAcute undiffentiated leukemia (AUL) is an acute leukemia with no more than one membrane marker of any given lineage. Blasts often express HLA-DR, CD34, and/or CD38 and may be positive for terminal deoxynucleotidyl transferase (TdT). The expression of CD34, HLA-DR, and CD38 has been shown in pro-T-ALL, although in this case, blasts should also express CD7 and cyCD3. However, some cases of T-ALL without CD3 in the cytoplasm and all TCR chain genes in germ line configuration are reported, features that fit well with a very early hematopoietic cell. We report a case of acute leukemia CD34+/−HLADR+CD7+CD38+cyCD3− in which a diagnosis of AUL was considered. However the blasts were also positive for CD99 and TCR delta gene rearrangement which was found on molecular studies. Therefore a differential diagnosis between AUL and an early cyCD3 negative T-ALL was debated.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdoi:10.1155/2011/230568en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420675/pdf/en_US
dash.licenseLAA
dc.titlePrethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Reporten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCase Reports in Hematologyen_US
dash.depositing.authorPreffer, Frederic Ira
dc.date.available2013-03-29T15:27:24Z
dc.identifier.doi10.1155/2011/230568*
dash.contributor.affiliatedPreffer, Frederic


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record