Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia

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Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia

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Title: Diffusion Tensor Imaging, Structural Connectivity, and Schizophrenia
Author: Whitford, Thomas; Kubicki, Marek R.; Shenton, Martha E. ORCID  0000-0003-4235-7879

Note: Order does not necessarily reflect citation order of authors.

Citation: Whitford, Thomas J., Marek Kubicki, and Martha E. Shenton. 2011. Diffusion tensor imaging, structural connectivity, and schizophrenia. Schizophrenia Research and Treatment 2011:709523.
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Abstract: A fundamental tenet of the “disconnectivity” theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi represent the primary infrastructure for long distance communication in the brain, abnormalities in these fiber bundles have been implicated in the etiology of schizophrenia. Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that enables the visualization of white matter macrostructure in vivo, and which has provided unprecedented insight into the existence and nature of white matter abnormalities in schizophrenia. The paper begins with an overview of DTI and more commonly used diffusion metrics and moves on to a brief review of the schizophrenia literature. The functional implications of white matter abnormalities are considered, particularly with respect to myelin's role in modulating the transmission velocity of neural discharges. The paper concludes with a speculative hypothesis about the relationship between gray and white matter abnormalities associated with schizophrenia.
Published Version: doi:10.1155/2011/709523
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420716/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10473956
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