Show simple item record

dc.contributor.authorWhitford, Thomas
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorShenton, Martha E.
dc.date.accessioned2013-03-29T15:35:49Z
dc.date.issued2011
dc.identifier.citationWhitford, Thomas J., Marek Kubicki, and Martha E. Shenton. 2011. Diffusion tensor imaging, structural connectivity, and schizophrenia. Schizophrenia Research and Treatment 2011:709523.en_US
dc.identifier.issn2090-2085en_US
dc.identifier.issn2090-2093en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10473956
dc.description.abstractA fundamental tenet of the “disconnectivity” theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi represent the primary infrastructure for long distance communication in the brain, abnormalities in these fiber bundles have been implicated in the etiology of schizophrenia. Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that enables the visualization of white matter macrostructure in vivo, and which has provided unprecedented insight into the existence and nature of white matter abnormalities in schizophrenia. The paper begins with an overview of DTI and more commonly used diffusion metrics and moves on to a brief review of the schizophrenia literature. The functional implications of white matter abnormalities are considered, particularly with respect to myelin's role in modulating the transmission velocity of neural discharges. The paper concludes with a speculative hypothesis about the relationship between gray and white matter abnormalities associated with schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdoi:10.1155/2011/709523en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420716/pdf/en_US
dash.licenseLAA
dc.titleDiffusion Tensor Imaging, Structural Connectivity, and Schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalSchizophrenia Research and Treatmenten_US
dash.depositing.authorWhitford, Thomas
dc.date.available2013-03-29T15:35:49Z
dc.identifier.doi10.1155/2011/709523*
dash.identifier.orcid0000-0003-4235-7879*
dash.contributor.affiliatedWhitford, T
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedShenton, Martha


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record