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dc.contributor.authorGhisolfi, Laura
dc.contributor.authorKeates, Andrew C.
dc.contributor.authorHu, Xingwang
dc.contributor.authorLee, Dong-ki
dc.contributor.authorLi, Chiang-Jia
dc.date.accessioned2013-03-29T18:03:15Z
dc.date.issued2012
dc.identifier.citationGhisolfi, Laura, Andrew C. Keates, Xingwang Hu, Dong-ki Lee, and Chiang J. Li. 2012. Ionizing radiation induces stemness in cancer cells. PLoS ONE 7(8): e43628.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10474253
dc.description.abstractThe cancer stem cell (CSC) model posits the presence of a small number of CSCs in the heterogeneous cancer cell population that are ultimately responsible for tumor initiation, as well as cancer recurrence and metastasis. CSCs have been isolated from a variety of human cancers and are able to generate a hierarchical and heterogeneous cancer cell population. CSCs are also resistant to conventional chemo- and radio-therapies. Here we report that ionizing radiation can induce stem cell-like properties in heterogeneous cancer cells. Exposure of non-stem cancer cells to ionizing radiation enhanced spherogenesis, and this was accompanied by upregulation of the pluripotency genes Sox2 and Oct3/4. Knockdown of Sox2 or Oct3/4 inhibited radiation–induced spherogenesis and increased cellular sensitivity to radiation. These data demonstrate that ionizing radiation can activate stemness pathways in heterogeneous cancer cells, resulting in the enrichment of a CSC subpopulation with higher resistance to radiotherapy.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0043628en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424153/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectDevelopmental Biologyen_US
dc.subjectStem Cellsen_US
dc.subjectMolecular Cell Biologyen_US
dc.subjectCellular Typesen_US
dc.subjectMedicineen_US
dc.subjectOncologyen_US
dc.subjectCancer Treatmenten_US
dc.subjectRadiation Therapyen_US
dc.subjectCancers and Neoplasmsen_US
dc.subjectGastrointestinal Tumorsen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectBasic Cancer Researchen_US
dc.subjectRadiotherapyen_US
dc.titleIonizing Radiation Induces Stemness in Cancer Cellsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorGhisolfi, Laura
dc.date.available2013-03-29T18:03:15Z
dc.identifier.doi10.1371/journal.pone.0043628*
dash.contributor.affiliatedLi, Chiang
dash.contributor.affiliatedGhisolfi, Laura
dash.contributor.affiliatedKeates, Andrew


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