Novel Locus FER Is Associated With Serum HMW Adiponectin Levels

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Novel Locus FER Is Associated With Serum HMW Adiponectin Levels

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Title: Novel Locus FER Is Associated With Serum HMW Adiponectin Levels
Author: Menzaghi, Claudia; Salvemini, Lucia; De Bonis, Concetta; Trischitta, Vincenzo; Qi, Lu; Hu, Frank B.

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Citation: Qi, Lu, Claudia Menzaghi, Lucia Salvemini, Concetta De Bonis, Vincenzo Trischitta, and Frank B. Hu. 2011. Novel locus FER is associated with serum HMW adiponectin levels. Diabetes 60(8): 2197-2201.
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Abstract: OBJECTIVE High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels. RESEARCH DESIGN AND METHODS We performed a genome-wide association study (GWAS) of serum HMW adiponectin levels in individuals of European ancestry drawn from the Nurses’ Health Study (NHS) (N = 1,591). The single nucleotide polymorphisms (SNPs) identified in the GWAS analysis were replicated in an independent cohort of Europeans (N = 626). We examined the associations of the identified variations with diabetes risk and metabolic syndrome. RESULTS We identified a novel locus near the FER gene (5q21) at a genome-wide significance level, best represented by SNP rs10447248 (P = 4.69 × 10−8). We also confirmed that variations near the adiponectin-encoding ADIPOQ locus (3q27) were related to serum HMW adiponectin levels. In addition, we found that FER SNP rs10447248 was related to HDL cholesterol levels (P = 0.009); ADIPOQ variation was associated with fasting glucose (P = 0.04), HDL cholesterol (P = 0.04), and a metabolic syndrome score (P = 0.002). CONCLUSIONS Our results suggest that different loci may be involved in regulation of circulating HMW adiponectin levels and provide novel insight into the mechanisms that affect HMW adiponectin homeostasis.
Published Version: doi:10.2337/db10-1645
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