dc.contributor.author | Qi, Lu | |
dc.contributor.author | Menzaghi, Claudia | |
dc.contributor.author | Salvemini, Lucia | |
dc.contributor.author | De Bonis, Concetta | |
dc.contributor.author | Trischitta, Vincenzo | |
dc.contributor.author | Hu, Frank B. | |
dc.date.accessioned | 2013-03-29T18:53:32Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Qi, Lu, Claudia Menzaghi, Lucia Salvemini, Concetta De Bonis, Vincenzo Trischitta, and Frank B. Hu. 2011. Novel locus FER is associated with serum HMW adiponectin levels. Diabetes 60(8): 2197-2201. | en_US |
dc.identifier.issn | 0012-1797 | en_US |
dc.identifier.issn | 1939-327X | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10482550 | |
dc.description.abstract | OBJECTIVE High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels. RESEARCH DESIGN AND METHODS We performed a genome-wide association study (GWAS) of serum HMW adiponectin levels in individuals of European ancestry drawn from the Nurses’ Health Study (NHS) (N = 1,591). The single nucleotide polymorphisms (SNPs) identified in the GWAS analysis were replicated in an independent cohort of Europeans (N = 626). We examined the associations of the identified variations with diabetes risk and metabolic syndrome. RESULTS We identified a novel locus near the FER gene (5q21) at a genome-wide significance level, best represented by SNP rs10447248 (P = 4.69 × 10−8). We also confirmed that variations near the adiponectin-encoding ADIPOQ locus (3q27) were related to serum HMW adiponectin levels. In addition, we found that FER SNP rs10447248 was related to HDL cholesterol levels (P = 0.009); ADIPOQ variation was associated with fasting glucose (P = 0.04), HDL cholesterol (P = 0.04), and a metabolic syndrome score (P = 0.002). CONCLUSIONS Our results suggest that different loci may be involved in regulation of circulating HMW adiponectin levels and provide novel insight into the mechanisms that affect HMW adiponectin homeostasis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Diabetes Association | en_US |
dc.relation.isversionof | doi:10.2337/db10-1645 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142072/pdf/ | en_US |
dc.relation.hasversion | http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-1645/-/DC1 | en_US |
dash.license | LAA | |
dc.title | Novel Locus FER Is Associated With Serum HMW Adiponectin Levels | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Diabetes | en_US |
dash.depositing.author | Qi, Lu | |
dc.date.available | 2013-03-29T18:53:32Z | |
dc.identifier.doi | 10.2337/db10-1645 | * |
dash.contributor.affiliated | Qi, Lu | |
dash.contributor.affiliated | Hu, Frank | |