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dc.contributor.authorQi, Lu
dc.contributor.authorMenzaghi, Claudia
dc.contributor.authorSalvemini, Lucia
dc.contributor.authorDe Bonis, Concetta
dc.contributor.authorTrischitta, Vincenzo
dc.contributor.authorHu, Frank B.
dc.date.accessioned2013-03-29T18:53:32Z
dc.date.issued2011
dc.identifier.citationQi, Lu, Claudia Menzaghi, Lucia Salvemini, Concetta De Bonis, Vincenzo Trischitta, and Frank B. Hu. 2011. Novel locus FER is associated with serum HMW adiponectin levels. Diabetes 60(8): 2197-2201.en_US
dc.identifier.issn0012-1797en_US
dc.identifier.issn1939-327Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10482550
dc.description.abstractOBJECTIVE High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels. RESEARCH DESIGN AND METHODS We performed a genome-wide association study (GWAS) of serum HMW adiponectin levels in individuals of European ancestry drawn from the Nurses’ Health Study (NHS) (N = 1,591). The single nucleotide polymorphisms (SNPs) identified in the GWAS analysis were replicated in an independent cohort of Europeans (N = 626). We examined the associations of the identified variations with diabetes risk and metabolic syndrome. RESULTS We identified a novel locus near the FER gene (5q21) at a genome-wide significance level, best represented by SNP rs10447248 (P = 4.69 × 10−8). We also confirmed that variations near the adiponectin-encoding ADIPOQ locus (3q27) were related to serum HMW adiponectin levels. In addition, we found that FER SNP rs10447248 was related to HDL cholesterol levels (P = 0.009); ADIPOQ variation was associated with fasting glucose (P = 0.04), HDL cholesterol (P = 0.04), and a metabolic syndrome score (P = 0.002). CONCLUSIONS Our results suggest that different loci may be involved in regulation of circulating HMW adiponectin levels and provide novel insight into the mechanisms that affect HMW adiponectin homeostasis.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/db10-1645en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142072/pdf/en_US
dc.relation.hasversionhttp://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-1645/-/DC1en_US
dash.licenseLAA
dc.titleNovel Locus FER Is Associated With Serum HMW Adiponectin Levelsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetesen_US
dash.depositing.authorQi, Lu
dc.date.available2013-03-29T18:53:32Z
dc.identifier.doi10.2337/db10-1645*
dash.contributor.affiliatedQi, Lu
dash.contributor.affiliatedHu, Frank


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