Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis
Neuman, Nicole A
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CitationNeuman, Nicole A, and Elizabeth Petri Henske. 2011. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis. EMBO Molecular Medicine 3(4): 189-200.
AbstractThe protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. Here, we propose that there are clinically relevant functions and targets of TSC1, TSC2 and Rheb, which are independent of mTOR. We present evidence that such non-canonical functions of the TSC-Rheb signalling network exist, propose a standard of evidence for these non-canonical functions, and discuss their potential clinical and therapeutic implications for patients with TSC and lymphangioleiomyomatosis (LAM).
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10482557
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