Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

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Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

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Title: Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis
Author: Neuman, Nicole A; Henske, Elizabeth Petri

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Citation: Neuman, Nicole A, and Elizabeth Petri Henske. 2011. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis. EMBO Molecular Medicine 3(4): 189-200.
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Abstract: The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. Here, we propose that there are clinically relevant functions and targets of TSC1, TSC2 and Rheb, which are independent of mTOR. We present evidence that such non-canonical functions of the TSC-Rheb signalling network exist, propose a standard of evidence for these non-canonical functions, and discuss their potential clinical and therapeutic implications for patients with TSC and lymphangioleiomyomatosis (LAM).
Published Version: doi:10.1002/emmm.201100131
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377068/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10482557
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