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dc.contributor.authorChoi, Anna Lai
dc.contributor.authorWeihe, Pal
dc.contributor.authorBudtz-Jørgensen, Esben
dc.contributor.authorJørgensen, Poul J.
dc.contributor.authorSalonen, Jukka T.
dc.contributor.authorTuomainen, Tomi-Pekka
dc.contributor.authorMurata, Katsuyuki
dc.contributor.authorNielsen, Hans Petur
dc.contributor.authorPetersen, Maria Skaalum
dc.contributor.authorAskham, Jórun
dc.contributor.authorGrandjean, Philippe
dc.date.accessioned2013-03-29T20:28:28Z
dc.date.issued2008
dc.identifier.citationChoi, Anna Lai, Pal Weihe, Esben Budtz-Jørgensen, Poul J. Jørgensen, Jukka T. Salonen, Tomi-Pekka Tuomainen, Katsuyuki Murata, Hans Petur Nielsen, Maria Skaalum Petersen, Jórun Askham, and Philippe Grandjean. 2009. Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men. Environmental Health Perspectives 117(3): 367-372.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10482585
dc.description.abstractBackground: Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. Objective: We examined 42 Faroese whaling men (30–70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whale meat. Methods: We assessed exposure levels from mercury analysis of toenails and whole blood (obtained at the time of clinical examination), and a hair sample collected 7 years previously. Outcome measures included heart rate variability (HRV), blood pressure (BP), common carotid intima-media thickness (IMT), and brainstem auditory evoked potentials (BAEP). We carried out multiple regression and structural equation model (SEM) analyses to determine the confounder-adjusted effect of mercury exposure. Taking into account correlations among related measures, we categorized exposure and outcomes in groups to derive latent exposure and response variables in SEMs. We used multiple regression analysis to compare the predictive validity of individual exposure biomarkers and the latent exposure variable on individual and latent outcomes. Results: The toenail mercury concentrations varied widely and had a geometric mean of 2.0 μg/g; hair concentrations averaged about 3-fold higher. Mercury exposure was significantly associated with increased BP and IMT. This effect was reflected by SEMs, but mercury in toenails tended to be the best effect predictor. Conclusions: The results support the notion that increased MeHg exposure promotes the development of cardiovascular disease.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi://10.1289/ehp.11608en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661905/pdf/en_US
dash.licenseLAA
dc.subjectcardiovascular physiologyen_US
dc.subjectevoked potentialsen_US
dc.subjectfood contaminationen_US
dc.subjectmethylmercuryen_US
dc.subjectneurotoxicityen_US
dc.subjectpilot whaleen_US
dc.subjectseafooden_US
dc.titleMethylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Menen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2013-03-29T20:28:28Z
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.11608*
dash.contributor.affiliatedChoi, Anna Lai
dash.contributor.affiliatedWeihe, Pal
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


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