Nanowire Biosensors for Label-Free, Real-Time, Ultrasensitive Protein Detection

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Nanowire Biosensors for Label-Free, Real-Time, Ultrasensitive Protein Detection

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Title: Nanowire Biosensors for Label-Free, Real-Time, Ultrasensitive Protein Detection
Author: Zheng, Gengfeng; Lieber, Charles M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Zheng, Gengfeng, and Charles M. Lieber. 2011. Nanowire biosensors for label-free, real-time, ultrasensitive protein detection. Methods in Molecular Biology 790:223-237.
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Abstract: Sensitive and quantitative analysis of proteins is central to disease diagnosis, drug screening, and proteomic studies. Among recent research advances exploiting new nanomaterials for biomolecule analysis, silicon nanowires (SiNWs), which are configured as field-effect transistors (FETs), have emerged as one of the most promising and powerful platforms for label-free, real-time, and highly sensitive electrical detection of proteins as well as many other biological species. Here, we describe a detailed protocol for realizing SiNW biosensors for protein detection that includes SiNW synthesis, FET device fabrication, surface receptor functionalization, and electrical sensing measurements. Moreover, incorporating both p-type and n-type SiNWs in the same sensor array provides a unique means of internal control for sensing signal verification.
Published Version: doi:10.1007/978-1-61779-319-6_18
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/21948419
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10482602
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