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dc.contributor.authorHansen, Susanne
dc.contributor.authorStrøm, Marin
dc.contributor.authorMaslova, Ekaterina
dc.contributor.authorMortensen, Erik Lykke
dc.contributor.authorGranström, Charlotta
dc.contributor.authorOlsen, Sjurdur F.
dc.date.accessioned2013-04-01T19:16:49Z
dc.date.issued2012
dc.identifier.citationHansen, Susanne, Marin Strøm, Ekaterina Maslova, Erik Lykke Mortensen, Charlotta Granström, and Sjurdur F. Olsen. 2012. A comparison of three methods to measure asthma in epidemiologic studies: results from the Danish National Birth Cohort. PLoS ONE 7(5): e36328.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10483996
dc.description.abstractAsthma is a heterogeneous outcome and how the condition should be measured to best capture clinically relevant disease in epidemiologic studies remains unclear. We compared three methods of measuring asthma in the Danish National Birth Cohort (n>50.000). When the children were 7 years old, the prevalence of asthma was estimated from a self-administered questionnaire using parental report of doctor diagnoses, ICD-10 diagnoses from a population-based hospitalization registry, and data on anti-asthmatic medication from a population-based prescription registry. We assessed the agreement between the methods using kappa statistics. Highest prevalence of asthma was found using the prescription registry (32.2%) followed by the self-report (12.0%) and the hospitalization registry (6.6%). We found a substantial non-overlap between the methods (kappa = 0.21–0.38). When all three methods were combined the asthma prevalence was 3.6%. In conclusion, self-reported asthma, ICD-10 diagnoses from a hospitalization registry and data on anti-asthmatic medication use from a prescription registry lead to different prevalences of asthma in the same cohort of children. The non-overlap between the methods may be due to different abilities of the methods to identify cases with different phenotypes, in which case they should be treated as separate outcomes in future aetiological studies.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0036328en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350521/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectPopulation Biologyen_US
dc.subjectEpidemiologyen_US
dc.subjectEpidemiological Methodsen_US
dc.subjectMedicineen_US
dc.subjectClinical Immunologyen_US
dc.subjectAllergy and Hypersensitivityen_US
dc.subjectClinical Research Designen_US
dc.subjectCohort Studiesen_US
dc.subjectLongitudinal Studiesen_US
dc.subjectProspective Studiesen_US
dc.subjectPediatric Epidemiologyen_US
dc.subjectSurvey Methodsen_US
dc.subjectPulmonologyen_US
dc.subjectAsthmaen_US
dc.titleA Comparison of Three Methods to Measure Asthma in Epidemiologic Studies: Results from the Danish National Birth Cohorten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorOlsen, Sjurdur F.
dc.date.available2013-04-01T19:16:49Z
dc.identifier.doi10.1371/journal.pone.0036328*
dash.contributor.affiliatedOlsen, Sjurdur


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