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dc.contributor.authorAndersen, Helle R.
dc.contributor.authorWohlfahrt-Veje, Christine
dc.contributor.authorDalgård, Christine
dc.contributor.authorChristiansen, Lene
dc.contributor.authorMain, Katharina M.
dc.contributor.authorNellemann, Christine
dc.contributor.authorMurata, Katsuyuki
dc.contributor.authorJensen, Tina K.
dc.contributor.authorSkakkebæk, Niels E.
dc.contributor.authorGrandjean, Philippe
dc.date.accessioned2013-04-01T19:52:31Z
dc.date.issued2012
dc.identifier.citationAndersen, Helle R., Christine Wohlfahrt-Veje, Christine Dalgård, Lene Christiansen, Katharina M. Main, Christine Nellemann, Katsuyuki Murata, Tina K. Jensen, Niels E. Skakkebæk, and Philippe Grandjean. 2012. Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. PLoS ONE 7(5): e36830.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10484016
dc.description.abstractBackground: Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides. Methods: Pregnant greenhouse-workers were categorized as high, medium, or not exposed to pesticides. Their children underwent a standardized examination at age 6-to-11 years, where blood pressure, skin folds, and other anthropometric parameters were measured. PON1-genotype was determined for 141 children (88 pesticide exposed and 53 unexposed). Serum was analyzed for insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP3), insulin and leptin. Body fat percentage was calculated from skin fold thicknesses. BMI results were converted to age and sex specific Z-scores. Results: Prenatally pesticide exposed children carrying the PON1 192R-allele had higher abdominal circumference, body fat content, BMI Z-scores, blood pressure, and serum concentrations of leptin and IGF-I at school age than unexposed children. The effects were related to the prenatal exposure level. For children with the PON1 192QQ genotype, none of the variables was affected by prenatal pesticide exposure. Conclusion: Our results indicate a gene-environment interaction between prenatal pesticide exposure and the PON1 gene. Only exposed children with the R-allele developed adverse cardiovascular risk profiles thought to be associated with the R-allele.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0036830en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352943/pdf/en_US
dash.licenseLAA
dc.subjectAgricultureen_US
dc.subjectAgrochemicalsen_US
dc.subjectPesticidesen_US
dc.subjectBiologyen_US
dc.subjectGeneticsen_US
dc.subjectPopulation Geneticsen_US
dc.subjectGenetic Polymorphismen_US
dc.subjectMedicineen_US
dc.subjectCardiovascularen_US
dc.subjectEpidemiologyen_US
dc.subjectEnvironmental Epidemiologyen_US
dc.subjectPediatric Epidemiologyen_US
dc.subjectMetabolic Disordersen_US
dc.subjectObstetrics and Gynecologyen_US
dc.subjectPregnancyen_US
dc.subjectPregnancy Complicationsen_US
dc.subjectPediatricsen_US
dc.subjectChild Developmenten_US
dc.subjectPublic Healthen_US
dc.subjectChild Healthen_US
dc.subjectEnvironmental Healthen_US
dc.subjectOccupational and Industrial Healthen_US
dc.subjectToxicologyen_US
dc.titleParaoxonase 1 Polymorphism and Prenatal Pesticide Exposure Associated with Adverse Cardiovascular Risk Profiles at School Ageen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2013-04-01T19:52:31Z
dc.identifier.doi10.1371/journal.pone.0036830*
dash.contributor.affiliatedGrandjean, Philippe


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