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dc.contributor.authorWang, Alice
dc.contributor.authorHolston, Alexander M.
dc.contributor.authorYu, Kai F.
dc.contributor.authorZhang, Jun
dc.contributor.authorToporsian, Mourad
dc.contributor.authorKarumanchi, Subbian Ananth
dc.contributor.authorLevine, Richard J.
dc.date.accessioned2013-04-05T15:10:28Z
dc.date.issued2012
dc.identifier.citationWang, Alice, Alexander M. Holston, Kai F. Yu, Jun Zhang, Mourad Toporsian, S. Ananth Karumanchi, and Richard J. Levine. 2012. Circulating anti-angiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonates. The Journal of Maternal-Fetal & Neonatal Medicine 25(8): 1447-1452.en_US
dc.identifier.issn1476-7058en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10498799
dc.description.abstractObjective: To test the hypothesis that high circulating concen-trations of maternal anti-angiogenic factors are associated with increased risk of respiratory distress syndrome (RDS). Study Design: This is a nested case-control study of nulliparous women who delivered less than 37 weeks of gestation within the Calcium for Preeclampsia Prevention (CPEP) trial. The study included 116 women with preeclampsia or gestational hyperten-sion and 323 normotensive controls. Soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF) and soluble endo-glin (sEng) in maternal serum were measured at 21–32 weeks of gestation. Results: Preterm infants born to hypertensive mothers were more likely to develop RDS (22.5% vs. 20.9%, p =0.03). After adjustment for gestational age at delivery, the odds ratio for the relationship between hypertension in pregnancy and RDS was 2.18 (95% CI 1.08–4.39). In hypertensive pregnancies women whose infants developed RDS had significantly higher circulating mean sFlt1 levels during midpregnancy (21–32 weeks of gestation) even after adjustment for gestational age at delivery (21,516 pg/mL vs. 7,000 pg/mL, p =0.01). Conclusions: Preterm preeclampsia and gestational hypertension, charac-terized by high circulating levels of sFlt1, are associated with a twofold increased risk of RDS in infants delivered before 37 weeks. Among women with these hypertensive pregnancies circulating sFlt1 concentrations during midpregnancy were substantially higher in women whose infants developed RDS.en_US
dc.language.isoen_USen_US
dc.publisherInforma healthcareen_US
dc.relation.isversionofdoi:10.3109/14767058.2011.640368en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414194/pdf/en_US
dash.licenseLAA
dc.subjectAnti-angiogenicen_US
dc.subjectsoluble fms-like tyrosine kinase 1en_US
dc.subjectsVEGF R1en_US
dc.subjectsFlt1en_US
dc.subjectplacental growth factoren_US
dc.subjectPlGFen_US
dc.subjectsoluble endoglinen_US
dc.subjectsEngen_US
dc.subjectrespiratory distress syndromeen_US
dc.subjectRDSen_US
dc.subjectneonateen_US
dc.subjectpretermen_US
dc.subjectpreeclampsiaen_US
dc.subjectgestational hypertensionen_US
dc.titleCirculating anti-angiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonatesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe Journal of Maternal-Fetal & Neonatal Medicineen_US
dash.depositing.authorKarumanchi, Subbian Ananth
dc.date.available2013-04-05T15:10:28Z
dc.identifier.doi10.3109/14767058.2011.640368*
dash.contributor.affiliatedToporsian, Mourad
dash.contributor.affiliatedKarumanchi, Subbian


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