dc.contributor.author | Massengale, Mei | |
dc.contributor.author | Lu, Bing | |
dc.contributor.author | Pan, John Jun-Hao | |
dc.contributor.author | Katz, Jeffrey Neil | |
dc.contributor.author | Solomon, Daniel Hal | |
dc.date.accessioned | 2013-04-08T17:29:56Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Massengale, Mei, Bing Lu, John J. Pan, Jeffrey N. Katz, and Daniel H. Solomon. 2012. Adipokine hormones and hand osteoarthritis: radiographic severity and pain. PLoS ONE 7(10): e47860. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10510850 | |
dc.description.abstract | Introduction: Obesity's association with hand osteoarthritis cannot be fully explained by mechanical loading. We examined the relationship between adipokines and radiographic hand osteoarthritis severity and pain. Methods: In a pilot study of 44 hand osteoarthritis patients (39 women and 5 men), serum adipokine concentrations and hand x-ray Kallman-scores were analyzed using linear regression models. Secondary analyses examined correlates of hand pain. Results: The cohort had a mean age of 63.5 years for women and 72.6 for men; mean (standard deviation) Kallman-scores were 43.3(17.4) for women and 46.2(10.8) for men. Mean body-mass-index was 30 kg/m2 for women and men. Mean leptin concentration was 32.2 ng/ml (women) and 18.5 ng/ml (men); mean adiponectin-total was 7.9 ng/ml (women) and 5.3 ng/ml (men); mean resistin was 7.3 ng/ml (women) and 9.4 ng/ml (men). No association was found between Kallman-scores and adipokine concentrations (R2 = 0.00–0.04 unadjusted analysis, all p-values>0.22). Secondary analyses showed mean visual-analog-scale pain of 4.8(2.4) for women and 6.6(0.9) for men. Leptin, BMI, and history of coronary artery disease were found to be associated with visual-analog-scale scores for chronic hand pain (R2 = 0.36 unadjusted analysis, p-values≤0.04). Conclusion: In this pilot study, we found that adipokine serum concentrations were not associated with hand osteoarthritis radiographic severity; the most important correlates of joint damage were age and disease duration. Leptin serum concentration, BMI, and coronary artery disease were associated with the intensity of chronic hand OA pain. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0047860 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482224/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Medicine | en_US |
dc.subject | Clinical Research Design | en_US |
dc.subject | Cohort Studies | en_US |
dc.subject | Neurology | en_US |
dc.subject | Pain Management | en_US |
dc.subject | Nutrition | en_US |
dc.subject | Obesity | en_US |
dc.subject | Radiology | en_US |
dc.subject | Diagnostic Radiology | en_US |
dc.subject | Rheumatology | en_US |
dc.subject | Osteoarthritis | en_US |
dc.title | Adipokine Hormones and Hand Osteoarthritis: Radiographic Severity and Pain | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Lu, Bing | |
dc.date.available | 2013-04-08T17:29:56Z | |
dc.identifier.doi | 10.1371/journal.pone.0047860 | * |
dash.contributor.affiliated | Pan, John Jun-Hao | |
dash.contributor.affiliated | Lu, Bing | |
dash.contributor.affiliated | Solomon, Daniel | |
dash.contributor.affiliated | Katz, Jeffrey | |