Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

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Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

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Title: Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
Author: Carr, Gavin; Derbyshire, Emily; Caldera, Eric; Currie, Cameron R.; Clardy, Jon C.

Note: Order does not necessarily reflect citation order of authors.

Citation: Carr, Gavin, Emily R. Derbyshire, Eric Caldera, Cameron R. Currie, and Jon Clardy. 2012. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of Natural Products 75(10): 1806-1809.
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Abstract: Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1–3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.
Published Version: doi:10.1021/np300380t
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481556/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10511078
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