Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
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CitationCarr, Gavin, Emily R. Derbyshire, Eric Caldera, Cameron R. Currie, and Jon Clardy. 2012. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of Natural Products 75(10): 1806-1809.
AbstractThree new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1–3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.
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