Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

DSpace/Manakin Repository

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

Citable link to this page

 

 
Title: Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice
Author: He, Chengwei; Qu, Xiying; Wan, Jianbo; Rong, Rong; Huang, Lili; Cai, Chun; Zhou, Keyuan; Gu, Yan; Qian, Steven Y.; Kang, Jing Xuan

Note: Order does not necessarily reflect citation order of authors.

Citation: He, Chengwei, Xiying Qu, Jianbo Wan, Rong Rong, Lili Huang, Chun Cai, Keyuan Zhou, Yan Gu, Steven Y. Qian, and Jing X. Kang. 2012. Inhibiting delta-6 desaturase activity suppresses tumor growth in mice. PLoS ONE 7(10): e47567.
Full Text & Related Files:
Abstract: Recent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n−6) arachidonic acid (AA). Although the metabolic pathways (COX, LOX, and P450) that generate these n−6 AA eicosanoids have been targeted, the role of endogenous AA production in tumorigenesis remains unexplored. Delta-6 desaturase (D6D) is the rate-limiting enzyme responsible for the synthesis of n−6 AA and increased D6D activity can lead to enhanced n−6 AA production. Here, we show that D6D activity is upregulated during melanoma and lung tumor growth and that suppressing D6D activity, either by RNAi knockdown or a specific D6D inhibitor, dramatically reduces tumor growth. Accordingly, the content of AA and AA-derived tumor-promoting metabolites is significantly decreased. Angiogenesis and inflammatory status are also reduced. These results identify D6D as a key factor for tumor growth and as a potential target for cancer therapy and prevention.
Published Version: doi:10.1371/journal.pone.0047567
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480421/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10511080
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters