Co-Operative Additive Effects between HLA Alleles in Control of HIV-1

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Co-Operative Additive Effects between HLA Alleles in Control of HIV-1

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Title: Co-Operative Additive Effects between HLA Alleles in Control of HIV-1
Author: Matthews, Philippa C.; Listgarten, Jennifer; Carlson, Jonathan M.; Payne, Rebecca; Huang, Kuan-Hsiang Gary; Frater, John; Goedhals, Dominique; Steyn, Dewald; van Vuuren, Cloete; Paioni, Paolo; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger L.; Mncube, Zenele; Ndung'u, Thumbi; Walker, Bruce David; Heckerman, David; Goulder, Philip J. R.

Note: Order does not necessarily reflect citation order of authors.

Citation: Matthews, Philippa C., Jennifer Listgarten, Jonathan M. Carlson, Rebecca Payne, Kuan-Hsiang Gary Huang, John Frater, Dominique Goedhals, et al. 2012. Co-operative additive effects between HLA alleles in control of HIV-1. PLoS ONE 7(10): e47799.
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Abstract: Background: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage disequilibrium, such as HLA-A*74 and HLA-B*57, appear to function co-operatively to result in greater immune control of HIV than mediated by either single allele alone. We here investigate the extent to which HLA alleles - irrespective of linkage disequilibrium - function co-operatively. Methodology/Principal Findings: We here refined a computational approach to the analysis of >2000 subjects infected with C-clade HIV first to discern the individual effect of each allele on disease control, and second to identify pairs of alleles that mediate ‘co-operative additive’ effects, either to improve disease suppression or to contribute to immunological failure. We identified six pairs of HLA class I alleles that have a co-operative additive effect in mediating HIV disease control and four hazardous pairs of alleles that, occurring together, are predictive of worse disease outcomes (q<0.05 in each case). We developed a novel ‘sharing score’ to quantify the breadth of CD8+ T cell responses made by pairs of HLA alleles across the HIV proteome, and used this to demonstrate that successful viraemic suppression correlates with breadth of unique CD8+ T cell responses (p = 0.03). Conclusions/Significance: These results identify co-operative effects between HLA Class I alleles in the control of HIV-1 in an extended Southern African cohort, and underline complementarity and breadth of the CD8+ T cell targeting as one potential mechanism for this effect.
Published Version: doi:10.1371/journal.pone.0047799
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477121/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10511100
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