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dc.contributor.authorWang, Hui
dc.contributor.authorYang, Yanping
dc.contributor.authorWang, Guanjun
dc.contributor.authorWang, Shumei
dc.contributor.authorYeap, Beow Yong
dc.contributor.authorSykes, Megan
dc.contributor.authorYang, Yong-Guang
dc.date.accessioned2013-04-08T19:24:32Z
dc.date.issued2012
dc.identifier.citationWang, Hui, Yanping Yang, Guanjun Wang, Shumei Wang, Beow Yong Yeap, Megan Sykes, and Yong-Guang Yang. 2012. Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras. PLoS ONE 7(10): e47120.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10511337
dc.description.abstractDelayed administration of donor lymphocyte infusion (DLI) to established mixed chimeras has been shown to achieve anti-tumor responses without graft-vs.-host disease (GVHD). Herein we show that de novo donor BM-derived T cells that are tolerant of the recipients are important in preventing GVHD in mixed chimeras receiving delayed DLI. Mixed chimeras lacking donor BM-derived T cells developed significantly more severe GVHD than those with donor BM-derived T cells after DLI, even though both groups had comparable levels of total T cells at the time of DLI. Post-DLI depletion of donor BM-derived T cells in mixed chimeras, as late as 20 days after DLI, also provoked severe GVHD. Although both CD4 and CD8 T cells contributed to the protection, the latter were significantly more effective, suggesting that inhibition of GVHD was not mainly mediated by CD4 regulatory T cells. The lack of donor BM-derived T cells was associated with markedly increased accumulation of DLI-derived alloreactive T cells in parenchymal GVHD target tissues. Thus, donor BM-derived T cells are an important factor in determining the risk of GVHD and therefore, offer a potential therapeutic target for preventing and ameliorating GVHD in the setting of delayed DLI in established mixed chimeras.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0047120en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471915/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectImmunologyen_US
dc.subjectImmune Cellsen_US
dc.subjectT Cellsen_US
dc.subjectImmunologic Subspecialtiesen_US
dc.subjectTransplantationen_US
dc.subjectImmunopathologyen_US
dc.subjectMedicineen_US
dc.subjectClinical Immunologyen_US
dc.subjectHematologyen_US
dc.subjectBone Marrow and Stem Cell Transplantationen_US
dc.subjectHematopoiesisen_US
dc.subjectOncologyen_US
dc.subjectCancer Treatmenten_US
dc.subjectBone Marrow Transplantationen_US
dc.titleDonor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimerasen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorYeap, Beow Yong
dc.date.available2013-04-08T19:24:32Z
dc.identifier.doi10.1371/journal.pone.0047120*
dash.authorsorderedfalse
dash.contributor.affiliatedYeap, Beow


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