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dc.contributor.authorManier, S.
dc.contributor.authorSacco, A.
dc.contributor.authorLeleu, X.
dc.contributor.authorGhobrial, Irene
dc.contributor.authorRoccaro, Aldo M.
dc.date.accessioned2013-04-08T19:36:56Z
dc.date.issued2012
dc.identifier.citationManier, S., A. Sacco, X. Leleu, I. M. Ghobrial, and A. M. Roccaro. 2012. Bone marrow microenvironment in multiple myeloma progression. Journal of Biomedicine and Biotechnology 2012:157496.en_US
dc.identifier.issn1110-7243en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10512165
dc.description.abstractSubstantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdoi:10.1155/2012/157496en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471001/pdf/en_US
dash.licenseLAA
dc.titleBone Marrow Microenvironment in Multiple Myeloma Progressionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Biomedicine and Biotechnologyen_US
dash.depositing.authorGhobrial, Irene
dc.date.available2013-04-08T19:36:56Z
dc.identifier.doi10.1155/2012/157496*
dash.contributor.affiliatedGhobrial, Irene
dash.contributor.affiliatedRoccaro, Aldo M.


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