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dc.contributor.authorAoi, Mikio C.
dc.contributor.authorHu, Kun
dc.contributor.authorLo, Men-Tzung
dc.contributor.authorSelim, Magdy H.
dc.contributor.authorOlufsen, Mette S.
dc.contributor.authorNovak, Vera
dc.date.accessioned2013-04-08T20:07:09Z
dc.date.issued2012
dc.identifier.citationAoi, Mikio C., Kun Hu, Men-Tzung Lo, Magdy Selim, Mette S. Olufsen, and Vera Novak. 2012. Impaired cerebral autoregulation is associated with brain atrophy and worse functional status in chronic ischemic stroke. PLoS ONE 7(10): e46794.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10512171
dc.description.abstractDynamic cerebral autoregulation (dCA) is impaired following stroke. However, the relationship between dCA, brain atrophy, and functional outcomes following stroke remains unclear. In this study, we aimed to determine whether impairment of dCA is associated with atrophy in specific regions or globally, thereby affecting daily functions in stroke patients. We performed a retrospective analysis of 33 subjects with chronic infarctions in the middle cerebral artery territory, and 109 age-matched non-stroke subjects. dCA was assessed via the phase relationship between arterial blood pressure and cerebral blood flow velocity. Brain tissue volumes were quantified from MRI. Functional status was assessed by gait speed, instrumental activities of daily living (IADL), modified Rankin Scale, and NIH Stroke Score. Compared to the non-stroke group, stroke subjects showed degraded dCA bilaterally, and showed gray matter atrophy in the frontal, parietal and temporal lobes ipsilateral to infarct. In stroke subjects, better dCA was associated with less temporal lobe gray matter atrophy on the infracted side ( = 0.029), faster gait speed ( = 0.018) and lower IADL score (0.002). Our results indicate that better dynamic cerebral perfusion regulation is associated with less atrophy and better long-term functional status in older adults with chronic ischemic infarctions.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0046794en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469603/pdf/en_US
dash.licenseLAA
dc.subjectEngineeringen_US
dc.subjectSignal Processingen_US
dc.subjectSignal Filteringen_US
dc.subjectMedicineen_US
dc.subjectCardiovascularen_US
dc.subjectStrokeen_US
dc.subjectNeurologyen_US
dc.subjectCerebrovascular Diseasesen_US
dc.subjectIschemic Strokeen_US
dc.subjectAutonomic Nervous Systemen_US
dc.subjectNeurorehabilitation and Traumaen_US
dc.subjectRadiologyen_US
dc.subjectDiagnostic Radiologyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleImpaired Cerebral Autoregulation Is Associated with Brain Atrophy and Worse Functional Status in Chronic Ischemic Strokeen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorHu, Kun
dc.date.available2013-04-08T20:07:09Z
dc.identifier.doi10.1371/journal.pone.0046794*
dash.contributor.affiliatedSelim, Magdy
dash.contributor.affiliatedHu, Kun
dash.contributor.affiliatedNovak, Vera


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