Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome

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Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome

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Title: Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome
Author: Kumar, Radhika; Dohlman, Claes Henrik; Chodosh, James

Note: Order does not necessarily reflect citation order of authors.

Citation: Kumar, Radhika, Claes H Dohlman, and James Chodosh. 2012. Oral acetazolamide after Boston keratoprosthesis in Stevens Johnson syndrome. BMC Research Notes 5: 205.
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Abstract: Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma. A retrospective case series is described of patients at the Massachusetts Eye and Ear Infirmary who underwent keratoprosthesis surgery for corneal blindness from SJS/TEN, and later required oral acetazolamide for elevated intraocular pressure. Findings: Over the last 10 years, 17 patients with SJS/TEN received a Boston keratoprosthesis. Of these, 11 developed elevated intraocular pressure that required administration of oral acetazolamide. One of 11 developed a mild allergic reaction, but no patient experienced a recurrence of SJS/TEN or any severe adverse reaction. Conclusion: Although an increase in the rate of recurrent SJS/TEN due to oral acetazolamide would not necessarily be apparent after treating only 11 patients, in our series, acetazolamide administration was well tolerated without serious sequela.
Published Version: doi:10.1186/1756-0500-5-205
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469385/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10512594
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