The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC

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The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC

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Title: The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC
Author: Sung, Chang Kyoo; Yim, Hyungshin; Gu, Hongcang; Li, Dawei; Andrews, Erik; Duraisamy, Sekhar; Li, Cheng; Drapkin, Ronny I.; Benjamin, Thomas L.

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Citation: Sung, Chang Kyoo, Hyungshin Yim, Hongcang Gu, Dawei Li, Erik Andrews, Sekhar Duraisamy, Cheng Li, Ronny Drapkin, and Thomas Benjamin. 2012. The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. PLoS ONE 7(9): e46486.
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Abstract: p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.
Published Version: doi:10.1371/journal.pone.0046486
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460914/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10522887
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