Regulation of ligand-independent notch signal through intracellular trafficking

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Regulation of ligand-independent notch signal through intracellular trafficking

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Title: Regulation of ligand-independent notch signal through intracellular trafficking
Author: Hori, Kazuya; Sen, Anindya Kumar; Kirchhausen, Tomas Leopold; Artavanis-Tsakonas, Spyros

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Citation: Hori, Kazuya, Anindya Sen, Tom Kirchhausen, and Spyros Artavanis-Tsakonas. 2012. Regulation of ligand-independent notch signal through intracellular trafficking. Communicative & Integrative Biology 5(4): 374-376.
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Abstract: Notch signaling is an evolutionarily conserved mechanism that defines a key cell fate control mechanism in metazoans. Notch signaling relies on the surface interaction between the Notch receptor and membrane bound ligands in an apposing cell. In our recent study, we uncover a non-canonical receptor activation path that relies on a ligand-independent, intracellular activation of the receptor as it travels through the endosomal compartments. We found that Notch receptor, targeted for degradation lysosomal degradation through multivesicular bodies (MVBs) is “diverted” toward activation upon mono-ubiquitination through a synergy between the ubiquitin ligase Deltex, the non-visual β-arrestin Kurtz and the ESCRT-III component Shrub. This activation path is not universal but appears to depend on the cellular context.
Published Version: doi:10.4161/cib.19995
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460843/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10522910
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