Loss of CCR7 Expression on \(CD56^{bright}\) NK Cells Is Associated with a \(CD56^{dim}CD16^{+}\) NK Cell-Like Phenotype and Correlates with HIV Viral Load

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Loss of CCR7 Expression on \(CD56^{bright}\) NK Cells Is Associated with a \(CD56^{dim}CD16^{+}\) NK Cell-Like Phenotype and Correlates with HIV Viral Load

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Title: Loss of CCR7 Expression on \(CD56^{bright}\) NK Cells Is Associated with a \(CD56^{dim}CD16^{+}\) NK Cell-Like Phenotype and Correlates with HIV Viral Load
Author: Hong, Henoch Sangjoon; Ahmad, Fareed; Eberhard, Johanna M.; Bhatnagar, Nupur; Bollmann, Benjamin A.; Keudel, Phillip; Ballmaier, Matthias; Zielinska-Skowronek, Margot; Schmidt, Reinhold E.; Meyer-Olson, Dirk

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Citation: Hong, Henoch S., Fareed Ahmad, Johanna M. Eberhard, Nupur Bhatnagar, Benjamin A. Bollmann, Phillip Keudel, Matthias Ballmaier, Margot Zielinska-Skowronek, Reinhold E. Schmidt, and Dirk Meyer-Olson. 2012. Loss of CCR7 expression on \(CD56^{bright}\) NK cells is associated with a \(CD56^{dim}CD16^{+}\) NK cell-like phenotype and correlates with HIV viral load. PLoS ONE 7(9): e44820.
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Abstract: NK cells are pivotal sentinels of the innate immune system and distinct subpopulations in peripheral blood have been described. A number of studies addressed HIV-induced alterations of NK cell phenotype and functionality mainly focusing on \(CD56^{dim}CD16^{+}\) and \(CD56^{-} CD16^{+}\) NK cells. However, the impact of HIV-infection on \(CD56^{bright}\) NK cells is less well understood. Here we report a rise of \(CD56^{bright}\) NK cells in HIV-infected individuals, which lack CCR7-expression and strongly correlate with HIV viral load. \(CCR7^{−} CD56^{bright}\) NK cells were characterized by increased cytolytic potential, higher activation states and a more differentiated phenotype. These cells thus acquired a number of features of \(CD56^{dim}CD16^{+}\) NK cells. Furthermore, \(CD56^{bright}\) NK cells from HIV patients exhibited higher degranulation levels compared to uninfected individuals. Thus, chronic HIV-infection is associated with a phenotypic and functional shift of \(CD56^{bright}\) NK cells, which provides a novel aspect of HIV-associated pathogenesis within the NK cell compartment.
Published Version: doi:10.1371/journal.pone.0044820
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447005/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10524258
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