An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure

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An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure

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Title: An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure
Author: Wu, Zhaofei; Xu, Yuanzhong; Zhu, Yaming; Sutton, Amy K.; Zhao, Rongjie; Lowell, Bradford Barr; Olson, David Paul; Tong, Qingchun

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Citation: Wu, Zhaofei, Yuanzhong Xu, Yaming Zhu, Amy K. Sutton, Rongjie Zhao, Bradford B. Lowell, David P. Olson, and Qingchun Tong. 2012. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS ONE 7(9): e45167.
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Abstract: Oxytocin neurons represent one of the major subsets of neurons in the paraventricular hypothalamus (PVH), a critical brain region for energy homeostasis. Despite substantial evidence supporting a role of oxytocin in body weight regulation, it remains controversial whether oxytocin neurons directly regulate body weight homeostasis, feeding or energy expenditure. Pharmacologic doses of oxytocin suppress feeding through a proposed melanocortin responsive projection from the PVH to the hindbrain. In contrast, deficiency in oxytocin or its receptor leads to reduced energy expenditure without feeding abnormalities. To test the physiological function of oxytocin neurons, we specifically ablated oxytocin neurons in adult mice. Our results show that oxytocin neuron ablation in adult animals has no effect on body weight, food intake or energy expenditure on a regular diet. Interestingly, male mice lacking oxytocin neurons are more sensitive to high fat diet-induced obesity due solely to reduced energy expenditure. In addition, despite a normal food intake, these mice exhibit a blunted food intake response to leptin administration. Thus, our study suggests that oxytocin neurons are required to resist the obesity associated with a high fat diet; but their role in feeding is permissive and can be compensated for by redundant pathways.
Published Version: doi:10.1371/journal.pone.0045167
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445456/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10524337
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