dc.contributor.author | Pawlak, Amanda C. | |
dc.contributor.author | Cosper, Arjola K. | |
dc.contributor.author | Deng, April | |
dc.contributor.author | Horick, Nora K. | |
dc.contributor.author | Le, Long Phi | |
dc.contributor.author | Dias-Santagata, Dora | |
dc.contributor.author | Selim, M. Angelica | |
dc.contributor.author | Iafrate, Anthony John | |
dc.contributor.author | Hoang, Mai P | |
dc.contributor.author | Mihm, Martin Charles | |
dc.contributor.author | Nguyen, Anh Thu | |
dc.date.accessioned | 2013-04-12T19:08:31Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Le, Long P., Dora Dias-Santagata, Amanda C. Pawlak, Arjola K. Cosper, Anh Thu Nguyen, M. Angelica Selim, April Deng et al. 2012. Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. PLoS ONE 7(10): e47290. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10528303 | |
dc.description.abstract | Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional therapeutic approaches. However, studies on genetic alterations and EGFR and Her2 status of apocrine-eccrine carcinomas are few in number. In addition, hormonal studies have not been comprehensive and performed only on certain subsets of apocrine-eccrine carcinomas. To investigate whether apocrine-eccrine carcinomas express hormonal receptors or possess activation of oncogenic pathways that can be targeted by available chemotherapeutic agent we performed immunohistochemistry for AR, PR, ER, EGFR, and HER2 expression; fluorescence in situ hybridization (FISH) for EGFR and ERBB2 gene amplification; and molecular analyses for recurrent mutations in 15 cancer genes including AKT-1, EGFR, PIK3CA, and TP53 on 54 cases of apocrine-eccrine carcinomas. They include 10 apocrine carcinomas, 7 eccrine carcinomas, 9 aggressive digital papillary adenocarcinomas, 10 hidradenocarcinomas, 11 porocarcinomas, 1 adenoid cystic carcinoma, 4 malignant chondroid syringomas, 1 malignant spiradenoma, and 1 malignant cylindroma. AR, ER, PR, EGFR and HER2 expression was seen in 36% (19/53), 27% (14/51), 16% (8/51), 85% (44/52) and 12% (6/52), respectively. Polysomy or trisomy of EGFR was detected by FISH in 30% (14/46). Mutations of AKT-1, PIK3CA, and TP53 were detected in 1, 3, and 7 cases, respectively (11/47, 23%). Additional investigation regarding the potential treatment of rare cases of apocrine-eccrine carcinomas with PI3K/Akt/mTOR pathway inhibitors, currently in clinical testing, may be of clinical interest. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0047290 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467209/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Biology | en_US |
dc.subject | Biochemistry | en_US |
dc.subject | Drug Discovery | en_US |
dc.subject | Medicine | en_US |
dc.subject | Dermatology | en_US |
dc.subject | Skin Neoplasms | en_US |
dc.subject | Malignant Skin Neoplasms | en_US |
dc.subject | Diagnostic Medicine | en_US |
dc.subject | Pathology | en_US |
dc.subject | Anatomical Pathology | en_US |
dc.subject | Surgical Pathology | en_US |
dc.subject | General Pathology | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Molecular Pathology | en_US |
dc.subject | Oncology | en_US |
dc.subject | Cancer Treatment | en_US |
dc.subject | Hormonal Therapy | en_US |
dc.subject | Cancers and Neoplasms | en_US |
dc.subject | Skin Tumors | en_US |
dc.title | Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Le, Long Phi | |
dc.date.available | 2013-04-12T19:08:31Z | |
dc.identifier.doi | 10.1371/journal.pone.0047290 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Mihm, Martin | |
dash.contributor.affiliated | Le, Long Phi | |
dash.contributor.affiliated | Dias-Santagata, Dora | |
dash.contributor.affiliated | Iafrate, Anthony | |
dash.contributor.affiliated | Hoang, Mai | |