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dc.contributor.authorBonmassar, Giorgio
dc.contributor.authorFujimoto, Kyoko
dc.contributor.authorGolby, Alexandra Jacqueline
dc.date.accessioned2013-04-15T18:18:20Z
dc.date.issued2012
dc.identifier.citationBonmassar, Giorgio, Kyoko Fujimoto, and Alexandra J. Golby. 2012. PTFOS: flexible and absorbable intracranial electrodes for magnetic resonance imaging. PLoS ONE 7(9): e41187.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10536042
dc.description.abstractIntracranial electrocortical recording and stimulation can provide unique knowledge about functional brain anatomy in patients undergoing brain surgery. This approach is commonly used in the treatment of medically refractory epilepsy. However, it can be very difficult to integrate the results of cortical recordings with other brain mapping modalities, particularly functional magnetic resonance imaging (fMRI). The ability to integrate imaging and electrophysiological information with simultaneous subdural electrocortical recording/stimulation and fMRI could offer significant insight for cognitive and systems neuroscience as well as for clinical neurology, particularly for patients with epilepsy or functional disorders. However, standard subdural electrodes cause significant artifact in MRI images, and concerns about risks such as cortical heating have generally precluded obtaining MRI in patients with implanted electrodes. We propose an electrode set based on polymer thick film organic substrate (PTFOS), an organic absorbable, flexible and stretchable electrode grid for intracranial use. These new types of MRI transparent intracranial electrodes are based on nano-particle ink technology that builds on our earlier development of an EEG/fMRI electrode set for scalp recording. The development of MRI-compatible recording/stimulation electrodes with a very thin profile could allow functional mapping at the individual subject level of the underlying feedback and feed forward networks. The thin flexible substrate would allow the electrodes to optimally contact the convoluted brain surface. Performance properties of the PTFOS were assessed by MRI measurements, finite difference time domain (FDTD) simulations, micro-volt recording, and injecting currents using standard electrocortical stimulation in phantoms. In contrast to the large artifacts exhibited with standard electrode sets, the PTFOS exhibited no artifact due to the reduced amount of metal and conductivity of the electrode/trace ink and had similar electrical properties to a standard subdural electrode set. The enhanced image quality could enable routine MRI exams of patients with intracranial electrode implantation and could also lead to chronic implantation solutions.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0041187en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440382/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectNeuroscienceen_US
dc.subjectNeuroimagingen_US
dc.subjectFmrien_US
dc.subjectChemistryen_US
dc.subjectElectrochemistryen_US
dc.subjectElectrochemical Cellsen_US
dc.subjectElectrodesen_US
dc.subjectComputer Scienceen_US
dc.subjectComputerized Simulationsen_US
dc.subjectEngineeringen_US
dc.subjectBioengineeringen_US
dc.subjectBiomedical Engineeringen_US
dc.subjectBionicsen_US
dc.subjectMedical Devicesen_US
dc.subjectHuman Factors Engineeringen_US
dc.subjectMan Computer Interfaceen_US
dc.subjectMedicineen_US
dc.subjectRadiologyen_US
dc.subjectDiagnostic Radiologyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectSurgeryen_US
dc.subjectNeurosurgeryen_US
dc.subjectSurgical Oncologyen_US
dc.titlePTFOS: Flexible and Absorbable Intracranial Electrodes for Magnetic Resonance Imagingen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorBonmassar, Giorgio
dc.date.available2013-04-15T18:18:20Z
dc.identifier.doi10.1371/journal.pone.0041187*
dash.contributor.affiliatedBonmassar, Giorgio
dash.contributor.affiliatedGolby, Alexandra


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