Lis1 is an initiation factor for dynein-driven organelle transport

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Lis1 is an initiation factor for dynein-driven organelle transport

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Title: Lis1 is an initiation factor for dynein-driven organelle transport
Author: Egan, Martin; Tan, Kaeling; Reck-Peterson, Samara Louise

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Citation: Egan, Martin, Kaeling Tan, and Samara Louise Reck-Peterson. 2012. Lis1 is an initiation factor for dynein-driven organelle transport. The Journal of Cell Biology 197(7): 971-982.
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Abstract: The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have been linked to neurological diseases. For example, lissencephaly is caused by mutations in the dynein-associated protein Lis1. In this paper, using the long, highly polarized hyphae of the filamentous fungus Aspergillus nidulans, we show that three morphologically and functionally distinct dynein cargos showed transport defects in the genetic absence of Lis1/nudF, raising the possibility that Lis1 is ubiquitously used for dynein-based transport. Surprisingly, both dynein and its cargo moved at normal speeds in the absence of Lis1 but with reduced frequency. Moreover, Lis1, unlike dynein and dynactin, was absent from moving dynein cargos, further suggesting that Lis1 is not required for dynein-based cargo motility once it has commenced. Based on these observations, we propose that Lis1 has a general role in initiating dynein-driven motility.
Published Version: doi:10.1083/jcb.201112101
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384415/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10578924
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