Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells

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Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells

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Title: Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells
Author: Pettengill, Matthew A; Lam, Verissa W.; Ollawa, Ikechukwu; Marques-da-Silva, Camila; Ojcius, David M.

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Citation: Pettengill, Matthew A., Verissa W. Lam, Ikechukwu Ollawa, Camila Marques-da-Silva, and David M. Ojcius. 2012. Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells. PLoS ONE 7(10): e48456.
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Abstract: Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.
Published Version: doi:10.1371/journal.pone.0048456
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484050/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10578926
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