Show simple item record

dc.contributor.authorGleimer, Michael
dc.contributor.authorvon Boehmer, Harald
dc.contributor.authorKreslavsky, Taras
dc.date.accessioned2013-04-18T18:28:00Z
dc.date.issued2012
dc.identifier.citationGleimer, Michael, Harald von Boehmer, and Taras Kreslavsky. 2012. PLZF controls the expression of a limited number of genes essential for NKT cell function. Frontiers in Immunology 3:374.en_US
dc.identifier.issn1664-3224en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10578991
dc.description.abstractNatural killer (NKT) T cells exhibit tissue distribution, surface phenotype, and functional responses that are strikingly different from those of conventional T cells. The transcription factor PLZF is responsible for most of these properties, as its ectopic expression in conventional T cells is sufficient to confer to them an NKT-like phenotype. The molecular program downstream of PLZF, however, is largely unexplored. Here we report that PLZF regulates the expression of a surprisingly small set of genes, many with known immune functions. This includes several established components of the NKT cell developmental program. Expression of the transcriptional regulators Id2, previously shown to be required for iNKT cell survival in the liver and c-Maf, which shapes the NKT cytokine profile, was compromised in PLZF-deficient cells. Ectopic expression of c-Maf complemented the cells’ defect in producing IL-4 and IL-10. PLZF also induced a program of cell surface receptors which shape the NKT cell’s response to external stimuli, including the costimulatory receptor ICOS and the cytokine receptors IL12rb1 and IL18r1. As an ensemble, the known functions of the molecules whose expression is affected by PLZF explain many defects observed in \(PLZF^{−/−}\) NKT cells.en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionofdoi:10.3389/fimmu.2012.00374en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528072/pdf/en_US
dash.licenseLAA
dc.subjectNKTen_US
dc.subjectPLZFen_US
dc.subjectc-Mafen_US
dc.subjectId2en_US
dc.subjectCXCR6en_US
dc.subjectICOSen_US
dc.subjectIL12Ren_US
dc.subjectIL18Ren_US
dc.titlePLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Functionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalFrontiers in Immunologyen_US
dash.depositing.authorvon Boehmer, Harald
dc.date.available2013-04-18T18:28:00Z
dc.identifier.doi10.3389/fimmu.2012.00374*
dash.contributor.affiliatedvon Boehmer, Harald


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record