Show simple item record

dc.contributor.authorZielinski, Brandon A.
dc.contributor.authorFroehlich, Alyson L.
dc.contributor.authorPrigge, Molly B. D.
dc.contributor.authorNielsen, Jared A.
dc.contributor.authorCooperrider, Jason R.
dc.contributor.authorCariello, Annahir N.
dc.contributor.authorAlexander, Andrew L.
dc.contributor.authorBigler, Erin D.
dc.contributor.authorLainhart, Janet E.
dc.contributor.authorAnderson, Jeffrey S.
dc.contributor.authorFletcher, P. Thomas
dc.contributor.authorLange, Nicholas Theodore
dc.date.accessioned2013-04-22T15:28:37Z
dc.date.issued2012
dc.identifier.citationZielinski, Brandon A., Jeffrey S. Anderson, Alyson L. Froehlich, Molly B. D. Prigge, Jared A. Nielsen, Jason R. Cooperrider, Annahir N. Cariello, et al. 2012. scMRI reveals large-scale brain network abnormalities in autism. PLoS ONE 7(11): e49172.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10579150
dc.description.abstractAutism is a complex neurological condition characterized by childhood onset of dysfunction in multiple cognitive domains including socio-emotional function, speech and language, and processing of internally versus externally directed stimuli. Although gross brain anatomic differences in autism are well established, recent studies investigating regional differences in brain structure and function have yielded divergent and seemingly contradictory results. How regional abnormalities relate to the autistic phenotype remains unclear. We hypothesized that autism exhibits distinct perturbations in network-level brain architecture, and that cognitive dysfunction may be reflected by abnormal network structure. Network-level anatomic abnormalities in autism have not been previously described. We used structural covariance MRI to investigate network-level differences in gray matter structure within two large-scale networks strongly implicated in autism, the salience network and the default mode network, in autistic subjects and age-, gender-, and IQ-matched controls. We report specific perturbations in brain network architecture in the salience and default-mode networks consistent with clinical manifestations of autism. Extent and distribution of the salience network, involved in social-emotional regulation of environmental stimuli, is restricted in autism. In contrast, posterior elements of the default mode network have increased spatial distribution, suggesting a ‘posteriorization’ of this network. These findings are consistent with a network-based model of autism, and suggest a unifying interpretation of previous work. Moreover, we provide evidence of specific abnormalities in brain network architecture underlying autism that are quantifiable using standard clinical MRI.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0049172en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504046/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectNeuroscienceen_US
dc.subjectDevelopmental Neuroscienceen_US
dc.subjectNeural Circuit Formationen_US
dc.subjectNeuroanatomyen_US
dc.subjectConnectomicsen_US
dc.subjectCognitive Neuroscienceen_US
dc.subjectNeural Networksen_US
dc.subjectNeuroimagingen_US
dc.subjectMedicineen_US
dc.subjectNeurologyen_US
dc.subjectPediatricsen_US
dc.subjectChild Developmenten_US
dc.subjectPublic Healthen_US
dc.subjectChild Healthen_US
dc.subjectRadiologyen_US
dc.subjectDiagnostic Radiologyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectPediatric Neurologyen_US
dc.subjectDevelopmental Neurologyen_US
dc.subjectBehavioral Aspects of Healthen_US
dc.subjectSocial Aspects of Healthen_US
dc.titlescMRI Reveals Large-Scale Brain Network Abnormalities in Autismen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorLange, Nicholas Theodore
dc.date.available2013-04-22T15:28:37Z
dc.identifier.doi10.1371/journal.pone.0049172*
dash.authorsorderedfalse
dash.contributor.affiliatedLange, Nicholas


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record