dc.contributor.author | Yamaki, Takahiko | |
dc.contributor.author | Kawasaki, Masanori | |
dc.contributor.author | Raffel, Owen Christopher | |
dc.contributor.author | Ishihara, Yoshiyuki | |
dc.contributor.author | Okubo, Munenori | |
dc.contributor.author | Kubota, Tomoki | |
dc.contributor.author | Hattori, Arihiro | |
dc.contributor.author | Nishigaki, Kazuhiko | |
dc.contributor.author | Takemura, Genzou | |
dc.contributor.author | Fujiwara, Hisayoshi | |
dc.contributor.author | Minatoguchi, Shinya | |
dc.contributor.author | Jang, Ik-Kyung | |
dc.date.accessioned | 2013-04-22T17:41:48Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Yamaki, Takahiko, Masanori Kawasaki, Ik-Kyung Jang, Owen Christopher Raffel, Yoshiyuki Ishihara, Munenori Okubo, Tomoki Kubota, et al. 2012. Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques. Cardiovascular Ultrasound 10:33. | en_US |
dc.identifier.issn | 1476-7120 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579214 | |
dc.description.abstract | Background: The purpose of this study was to determine the cut-off values of Hounsfield units (HU) for the discrimination of plaque components and to evaluate the feasibility of measurement of the volume of plaque components using multi-detector row computed tomography (MDCT). Methods: Coronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components. Results: Plaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18 ± 18 HU (−19 to 58 HU), 95 ± 24 HU (46 to 154 HU) and 378 ± 99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p <0.001), whereas fibrous volume was not (r =0.21, p =0.059). Conclusion: Lipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.isversionof | doi:10.1186/1476-7120-10-33 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495226/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Computed tomography | en_US |
dc.subject | Integrated backscatter | en_US |
dc.subject | Intravascular ultrasound | en_US |
dc.subject | Coronary plaque | en_US |
dc.title | Comparison between Integrated Backscatter Intravascular Ultrasound and 64-Slice Multi-Detector Row Computed Tomography for Tissue Characterization and Volumetric Assessment of Coronary Plaques | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Cardiovascular Ultrasound | en_US |
dash.depositing.author | Jang, Ik-Kyung | |
dc.date.available | 2013-04-22T17:41:48Z | |
dc.identifier.doi | 10.1186/1476-7120-10-33 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Jang, Ik-Kyung | |