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dc.contributor.authorYamaki, Takahiko
dc.contributor.authorKawasaki, Masanori
dc.contributor.authorRaffel, Owen Christopher
dc.contributor.authorIshihara, Yoshiyuki
dc.contributor.authorOkubo, Munenori
dc.contributor.authorKubota, Tomoki
dc.contributor.authorHattori, Arihiro
dc.contributor.authorNishigaki, Kazuhiko
dc.contributor.authorTakemura, Genzou
dc.contributor.authorFujiwara, Hisayoshi
dc.contributor.authorMinatoguchi, Shinya
dc.contributor.authorJang, Ik-Kyung
dc.date.accessioned2013-04-22T17:41:48Z
dc.date.issued2012
dc.identifier.citationYamaki, Takahiko, Masanori Kawasaki, Ik-Kyung Jang, Owen Christopher Raffel, Yoshiyuki Ishihara, Munenori Okubo, Tomoki Kubota, et al. 2012. Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques. Cardiovascular Ultrasound 10:33.en_US
dc.identifier.issn1476-7120en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10579214
dc.description.abstractBackground: The purpose of this study was to determine the cut-off values of Hounsfield units (HU) for the discrimination of plaque components and to evaluate the feasibility of measurement of the volume of plaque components using multi-detector row computed tomography (MDCT). Methods: Coronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components. Results: Plaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18 ± 18 HU (−19 to 58 HU), 95 ± 24 HU (46 to 154 HU) and 378 ± 99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p <0.001), whereas fibrous volume was not (r =0.21, p =0.059). Conclusion: Lipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1476-7120-10-33en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495226/pdf/en_US
dash.licenseLAA
dc.subjectComputed tomographyen_US
dc.subjectIntegrated backscatteren_US
dc.subjectIntravascular ultrasounden_US
dc.subjectCoronary plaqueen_US
dc.titleComparison between Integrated Backscatter Intravascular Ultrasound and 64-Slice Multi-Detector Row Computed Tomography for Tissue Characterization and Volumetric Assessment of Coronary Plaquesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCardiovascular Ultrasounden_US
dash.depositing.authorJang, Ik-Kyung
dc.date.available2013-04-22T17:41:48Z
dc.identifier.doi10.1186/1476-7120-10-33*
dash.authorsorderedfalse
dash.contributor.affiliatedJang, Ik-Kyung


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