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dc.contributor.authorLuo, Yi-Juan
dc.contributor.authorHe, Yan-Hui
dc.contributor.authorXie, Chuan-Bo
dc.contributor.authorLin, Jian-miao
dc.contributor.authorYuan, Shi-Xin
dc.contributor.authorGuo, Xiao-Ling
dc.contributor.authorJia, De-Qin
dc.contributor.authorChen, Li-Hua
dc.contributor.authorHuang, Bao-Zhen
dc.contributor.authorChen, Wei-Qing
dc.contributor.authorWen, Xiaozhong
dc.contributor.authorDing, Peng
dc.contributor.authorLiu, Tao
dc.date.accessioned2013-04-22T18:48:46Z
dc.date.issued2012
dc.identifier.citationLuo, Yi-Juan, Xiao-Zhong Wen, Peng Ding, Yan-Hui He, Chuan-Bo Xie, Tao Liu, Jian-miao Lin, et al. 2012. Interaction between maternal passive smoking during pregnancy and CYP1A1 and GSTs polymorphisms on spontaneous preterm delivery. PLoS ONE 7(11): e49155.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10579235
dc.description.abstractObjective: The present study aimed to examine the association between maternal passive smoking during pregnancy and the risk of spontaneous PTD and to explore the potential interaction of the single or joint gene polymorphism of CYP1A1 and GSTs with maternal passive smoking on the risk of spontaneous PTD. Method: We investigated whether the association between maternal passive smoking and PTD can be modified by 2 metabolic genes, i.e. cytochrome P4501A1 (CYP1A1) and glutathione S-transferases (GSTs), in a case-control study with 198 spontaneous preterm and 524 term deliveries in Shenzhen and Foshan, China. We used logistic regression to test gene-passive smoking interaction, adjusting for maternal socio-demographics and prepregnancy body mass index. Results: Overall, maternal passive smoking during pregnancy was associated with higher risk of PTD (adjusted odds ratio = 2.20 [95% confidence interval: 1.56–3.12]). This association was modified by CYP1A1 and GSTs together, but not by any single genotype. For cross-categories of CYP1A1 Msp I and GSTs, maternal passive smoking was associated with higher risk of PTD among those women with CYP1A1 “TC/CC”+ GSTs “null”, but not among women with other genotypes; and this interaction was significant (OR = 2.66 [95% CI: 1.19–5.97]; P-value: 0.017). For cross-categories of CYP1A1 BsrD I and GSTs, maternal passive smoking was associated with higher risk of PTD only among those women with CYP1A1“AG/GG”+ GSTs “null”, but not among women with other genotypes; and this interaction was significant (OR = 3.00 [95% CI: 1.17–7.74]; P-value: 0.023). Conclusions: Our findings suggest that the combined genotypes of CYP1A1 and GSTs can help to identify vulnerable pregnant women who are subject to high risk of spontaneous PTD due to passive smoking.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0049155en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496734/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectGeneticsen_US
dc.subjectGene Functionen_US
dc.subjectMolecular Cell Biologyen_US
dc.subjectCellular Stress Responsesen_US
dc.subjectMedicineen_US
dc.subjectEpidemiologyen_US
dc.subjectGenetic Epidemiologyen_US
dc.subjectMolecular Epidemiologyen_US
dc.subjectPediatric Epidemiologyen_US
dc.subjectObstetrics and Gynecologyen_US
dc.subjectPregnancyen_US
dc.subjectPreterm Laboren_US
dc.subjectPulmonologyen_US
dc.subjectSmoking Related Disordersen_US
dc.titleInteraction between Maternal Passive Smoking during Pregnancy and CYP1A1 and GSTs Polymorphisms on Spontaneous Preterm Deliveryen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorWen, Xiaozhong
dc.date.available2013-04-22T18:48:46Z
dc.identifier.doi10.1371/journal.pone.0049155*
dash.authorsorderedfalse
dash.contributor.affiliatedWen, Xiaozhong
dash.contributor.affiliatedLiu, Tao


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