Detection of Murine Post-Pneumonectomy Lung Regeneration by 18FDG PET Imaging

DSpace/Manakin Repository

Detection of Murine Post-Pneumonectomy Lung Regeneration by 18FDG PET Imaging

Citable link to this page


Title: Detection of Murine Post-Pneumonectomy Lung Regeneration by 18FDG PET Imaging
Author: Gibney, Barry C; Chamoto, Kenji; Ysasi, Alexandra; Konerding, Moritz A; Park, Mi-Ae; Tsuda, Akira; Mentzer, Steven James

Note: Order does not necessarily reflect citation order of authors.

Citation: Gibney, Barry C., Mi-Ae Park, Kenji Chamoto, Alexandra Ysasi, Moritz A. Konerding, Akira Tsuda, and Steven J. Mentzer. 2012. Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging. EJNMMI Research 2:48.
Full Text & Related Files:
Abstract: Background: An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung regeneration is largely unknown. Methods: To determine if murine lung regeneration could be detected in vivo, we studied inbred mice 3, 7, 14, and 21 days after left pneumonectomy. The remaining lung was imaged using microCT as well as the glucose tracer 2-deoxy-2-[18 F]fluoro-d-glucose (18FDG) and positron-emission tomography (PET). Because of the compliance of the murine chest wall, reproducible imaging required orotracheal intubation and pressure-controlled ventilation during scanning. Results: After left pneumonectomy, the right lung progressively enlarged over the first 3 weeks. The cardiac lobe demonstrated the greatest percentage increase in size. Dry weights of the individual lobes largely mirrored the increase in lung volume. PET/CT imaging was used to identify enhanced metabolic activity within the individual lobes. In the cardiac lobe, 18FDG uptake was significantly increased in the day 14 cardiac lobe relative to preoperative values (p < .05). In contrast, the 18FDG uptake in the other three lobes was not statistically significant at any time point. Conclusions: We conclude that the cardiac lobe is the dominant contributor to compensatory growth after murine pneumonectomy. Further, PET/CT scanning can detect both the volumetric increase and the metabolic changes associated with the regenerative growth in the murine cardiac lobe.
Published Version: doi:10.1186/2191-219X-2-48
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search