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dc.contributor.authorBedoret, Denis
dc.contributor.authorSingh, A K
dc.contributor.authorShaw, V
dc.contributor.authorHoyte, E G
dc.contributor.authorHamilton, R
dc.contributor.authorDeKruyff, Rosemarie H.
dc.contributor.authorSchneider, Lynda C.
dc.contributor.authorNadeau, K C
dc.contributor.authorUmetsu, Dale T.
dc.date.accessioned2013-04-22T20:11:06Z
dc.date.issued2012
dc.identifier.citationBedoret, D, A K Singh, V Shaw, E G Hoyte, R Hamilton, R H DeKruyff, L C Schneider, K C Nadeau, and D T Umetsu. 2012. Changes in antigen-specific T cell number and function during oral desensitization in cow’s milk allergy enabled with omalizumab. Mucosal Immunology 5(3): 267-276.en_US
dc.identifier.issn1933-0219en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10579379
dc.description.abstractFood allergy is a major public health problem for which there is no effective treatment. We examined the immunological changes that occurred in a group of children with significant cow’s milk allergy undergoing a novel and rapid high dose oral desensitization protocol enabled by treatment with omalizumab (anti-IgE mAb). Within a week of treatment, the CD4+ T cell response to milk was nearly eliminated, suggesting anergy in, or deletion of, milk-specific CD4+ T cells. Over the following three months while the subjects remained on high doses of daily oral milk, the CD4+ T cell response returned, characterized by a shift from IL-4 to IFN-γ production. Desensitization was also associated with reduction in milk-specific IgE and a 15-fold increase in milk-specific IgG4. These studies suggest that high dose oral allergen desensitization may be associated with deletion of allergen-specific T cells, without the apparent development of allergen-specific Foxp3+ regulatory T cells.en_US
dc.language.isoen_USen_US
dc.relation.isversionofdoi:10.1038/mi.2012.5en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328586/pdf/en_US
dash.licenseLAA
dc.titleChanges in antigen-specific T cell number and function during oral desensitization in cow’s milk allergy enabled with omalizumaben_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalMucosal Immunologyen_US
dash.depositing.authorDeKruyff, Rosemarie H.
dc.date.available2013-04-22T20:11:06Z
dc.identifier.doi10.1038/mi.2012.5*
dash.contributor.affiliatedBedoret, Denis
dash.contributor.affiliatedDeKruyff, Rosemarie H.
dash.contributor.affiliatedUmetsu, Dale
dash.contributor.affiliatedSchneider, Lynda


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