Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Sylvia, Katelyn E.
Yin, Catherine C.
Berg, Leslie J.
Kang, JoonsooNote: Order does not necessarily reflect citation order of authors.
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CitationNarayan, Kavitha, Katelyn E. Sylvia, Nidhi Malhotra, Catherine C. Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, et al. 2012. Intrathymic programming of effector fates in three molecularly distinct γδ t cell subtypes. Nature Immunology 13(5): 511-518.
Abstractγδ T cells function in the early phase of immune responses. Although innate γδ T cells have primarily been studied as one homogenous population, they can be functionally classified into effector subsets based on the production of signature cytokines, analogous to adaptive T helper subsets. Unlike adaptive T cells, however, γδ T effector function correlates with genomically encoded TCR chains, suggesting that clonal TCR selection is not the primary determinant of γδ effector differentiation. A high resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated based on TCRγ/δ chain usage indicates the existence of three separate subtypes of γδ effectors in the thymus. The immature γδ subsets are distinguished by unique transcription factor modules that program effector function.
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