Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes

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Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes

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Title: Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Author: Narayan, Kavitha; Sylvia, Katelyn E.; Malhotra, Nidhi; Yin, Catherine C.; Martens, Gregory; Vallerskog, Therese; Kornfeld, Hardy; Xiong, Na; Cohen, Nadia Rachel; Brenner, Michael Barry; Berg, Leslie J.; Kang, Joonsoo

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Citation: Narayan, Kavitha, Katelyn E. Sylvia, Nidhi Malhotra, Catherine C. Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, et al. 2012. Intrathymic programming of effector fates in three molecularly distinct γδ t cell subtypes. Nature Immunology 13(5): 511-518.
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Abstract: γδ T cells function in the early phase of immune responses. Although innate γδ T cells have primarily been studied as one homogenous population, they can be functionally classified into effector subsets based on the production of signature cytokines, analogous to adaptive T helper subsets. Unlike adaptive T cells, however, γδ T effector function correlates with genomically encoded TCR chains, suggesting that clonal TCR selection is not the primary determinant of γδ effector differentiation. A high resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated based on TCRγ/δ chain usage indicates the existence of three separate subtypes of γδ effectors in the thymus. The immature γδ subsets are distinguished by unique transcription factor modules that program effector function.
Published Version: doi:10.1038/ni.2247
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427768/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579384
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