Kim-1/Tim-1 and Immune Cells: Shifting Sands
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CitationIchimura, Takaharu, Craig Brooks, and Joseph Vincent Bonventre. 2012. Kim-1/Tim-1 and immune cells: Shifting sands. Kidney International 81(9): 809-811.
AbstractKim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.
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