A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis

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A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis

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Title: A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis
Author: Boström, Pontus; Wu, Jun; Jedrychowski, Mark P.; Korde, Anisha; Ye, Li; Lo, James C; Rasbach, Kyle A.; Boström, Elisabeth Almer; Choi, Jang Hyun; Long, Jonathan Zhong; Kajimura, Shingo; Zingaretti, Maria Cristina; Vind, Birgitte F.; Tu, Hua; Cinti, Saverio; Højlund, Kurt; Gygi, Steven P.; Spiegelman, Bruce Michael

Note: Order does not necessarily reflect citation order of authors.

Citation: Boström, Pontus, Jun Wu, Mark P. Jedrychowski, Anisha Korde, Li Ye, James C. Lo, Kyle A. Rasbach, et al. 2012. A PGC1-\(\alpha\)-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481(7382): 463-468.
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Abstract: Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.
Published Version: doi:10.1038/nature10777
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522098/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579551
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