Show simple item record

dc.contributor.authorGoldstein, Edward
dc.contributor.authorWallinga, J.
dc.contributor.authorLipsitch, Marc
dc.date.accessioned2013-04-23T18:53:14Z
dc.date.issued2012
dc.identifier.citationGoldstein, E., J. Wallinga, and M. Lipsitch. 2012. Vaccine allocation in a declining epidemic. Journal of the Royal Society Interface 9(76): 2798-2803.en_US
dc.identifier.issn1742-5689en_US
dc.identifier.issn1742-5662en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10579678
dc.description.abstractSizeable quantities of 2009 pandemic influenza A/H1N1 (H1N1pdm) vaccine in the USA became available at the end of 2009 when the autumn wave of the epidemic was declining. At that point, risk factors for H1N1-related mortality for some of the high-risk groups, particularly adults with underlying health conditions, could be estimated. Although those high-risk groups are natural candidates for being in the top priority tier for vaccine allocation, another candidate group is school-aged children through their role as vectors for transmission affecting the whole community. In this paper, we investigate the question of prioritization for vaccine allocation in a declining epidemic between two groups—a group with a high risk of mortality versus a ‘core’ group with a relatively low risk of mortality but fuelling transmission in the community. We show that epidemic data can be used, under certain assumptions on future decline, seasonality and vaccine efficacy in different population groups, to give a criterion when initial prioritization of a population group with a sufficiently high risk of epidemic-associated mortality is advisable over the policy of prioritizing the core group.en_US
dc.language.isoen_USen_US
dc.publisherThe Royal Societyen_US
dc.relation.isversionofdoi:10.1098/rsif.2012.0404en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479926/pdf/en_US
dash.licenseLAA
dc.subjectinfluenza pandemicen_US
dc.subjectvaccinationen_US
dc.subjecthigh risken_US
dc.subjectmortalityen_US
dc.titleVaccine Allocation in a Declining Epidemicen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of the Royal Society Interfaceen_US
dash.depositing.authorLipsitch, Marc
dc.date.available2013-04-23T18:53:14Z
dc.identifier.doi10.1098/rsif.2012.0404*
dash.contributor.affiliatedGoldstein, Edward
dash.contributor.affiliatedLipsitch, Marc


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record