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dc.contributor.authorLange, Nancy E
dc.contributor.authorSordillo, Joanne
dc.contributor.authorTarantini, Letizia
dc.contributor.authorBollati, Valentina
dc.contributor.authorSparrow, David
dc.contributor.authorVokonas, Pantel
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorLitonjua, Augusto Ampil
dc.contributor.authorDemeo, Dawn Lisa
dc.date.accessioned2013-04-24T18:55:41Z
dc.date.issued2012
dc.identifier.citationLange, Nancy E, Joanne Sordillo, Letizia Tarantini, Valentina Bollati, David Sparrow, Pantel Vokonas, Antonella Zanobetti, et al. 2012. Alu and LINE-1 methylation and lung function in the normative ageing study. BMJ Open 2(5): e001231.en_US
dc.identifier.issn2044-6055en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10581400
dc.description.abstractObjectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration facilities in greater Boston, Massachusetts, USA. Participants: Individuals from the Veterans Administration Normative Aging Study, a longitudinal study of aging in men, evaluated between 1999 and 2007. The majority (97%) were white. Primary and secondary outcome measures: Primary predictor was methylation, assessed using PCR-pyrosequencing after bisulphite treatment. Primary outcome was lung function as assessed by spirometry, performed according to American Thoracic Society/European Respiratory Society guidelines at the same visit as the blood draws. Results: In multivariable models adjusted for age, height, body mass index (BMI), pack-years of smoking, current smoking and race, Alu hypomethylation was associated with lower forced expiratory volume in 1 s (FEV1) (β=28 ml per 1% change in Alu methylation, p=0.017) and showed a trend towards association with a lower forced vital capacity (FVC) (β=27 ml, p=0.06) and lower FEV1/FVC (β=0.3%, p=0.058). In multivariable models adjusted for age, height, BMI, pack-years of smoking, current smoking, per cent lymphocytes, race and baseline lung function, LINE-1 hypomethylation was associated with more rapid decline of FEV1 (β=6.9 ml/year per 1% change in LINE-1 methylation, p=0.005) and of FVC (β=9.6 ml/year, p=0.002). Conclusions: In multiple regression analysis, Alu hypomethylation was associated with lower lung function, and LINE-1 hypomethylation was associated with more rapid lung function decline in a cohort of older and primarily white men from North America. Future studies should aim to replicate these findings and determine if Alu or LINE-1 hypomethylation may be due to specific and modifiable environmental exposures.en_US
dc.language.isoen_USen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.isversionofdoi:10.1136/bmjopen-2012-001231en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488751/pdf/en_US
dash.licenseLAA
dc.subjectEpidemiologyen_US
dc.subjectGeneticsen_US
dc.titleAlu and LINE-1 methylation and lung function in the normative ageing studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMJ Openen_US
dash.depositing.authorSchwartz, Joel David
dc.date.available2013-04-24T18:55:41Z
dc.identifier.doi10.1136/bmjopen-2012-001231*
dash.authorsorderedfalse
dash.contributor.affiliatedSordillo, Joanne
dash.contributor.affiliatedDemeo, Dawn
dash.contributor.affiliatedVokonas, Pantel
dash.contributor.affiliatedSparrow, David
dash.contributor.affiliatedLange, Nancy E
dash.contributor.affiliatedLitonjua, Augusto A.
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedBaccarelli, Andrea
dash.contributor.affiliatedZanobetti, Antonella


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