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dc.contributor.authorMacLeod, Iain James
dc.contributor.authorRowley, Christopher Francis
dc.contributor.authorLockman, Shahin
dc.contributor.authorOgwu, Anthony
dc.contributor.authorMoyo, Sikhulile
dc.contributor.authorvan Widenfelt, Erik
dc.contributor.authorMmalane, Mompati
dc.contributor.authorMakhema, Joseph Moeketsi
dc.contributor.authorEssex, Myron Elmer
dc.contributor.authorShapiro, Roger L.
dc.date.accessioned2013-04-25T18:47:30Z
dc.date.issued2012
dc.identifier.citationMacLeod, Iain J., Christopher F. Rowley, Shahin Lockman, Anthony Ogwu, Sikhulile Moyo, Erik van Widenfelt, Mompati Mmalane, Joseph Makhema, M. Essex, and Roger L. Shapiro. 2012. Abacavir alters the transcription of inflammatory cytokines in virologically suppressed, HIV-infected women. Journal of the International AIDS Society 15(2): 17393.en_US
dc.identifier.issn1758-2652en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10587998
dc.description.abstractBackground: Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation. Methods: To evaluate the induction of inflammatory cytokine transcription by ABC, we used samples from women randomized to receive zidovudine/lamivudine/ABC (Trizivir) or lopinavir/ritonavir and zidovudine/lamividine (Kaletra/Combivir) from the third trimester through six-months postpartum for the prevention of mother-to-child transmission (PMTCT). Women were matched by CD4 count and baseline HIV RNA. All women attained viral suppression (<50 copies/ml) by the time of sampling. Results: Four cytokines showed a difference in expression between the treatment arms, all in a proinflammatory direction for the ABC arm: CD40LG 1.82-fold, (p=.027); IL-8 3.16-fold (p=.020); LTA 2.82-fold, (p=.008); and CCL5 −1.67-fold, (p=.035). At 12-months postpartum, 6-months after antiretroviral discontinuation, cytokine expression was similar by treatment arm. Conclusions: We conclude that ABC may upregulate proinflammatory cytokines at the transcriptional level in this population.en_US
dc.language.isoen_USen_US
dc.publisherInternational AIDS Societyen_US
dc.relation.isversionofdoi:10.7448/IAS.15.2.17393en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499794/pdf/en_US
dash.licenseLAA
dc.subjectHIVen_US
dc.subjectabacaviren_US
dc.subjectcytokineen_US
dc.subjecttranscriptionen_US
dc.subjectantiretroviralen_US
dc.subjectinflammationen_US
dc.subjectAIDSen_US
dc.titleAbacavir Alters the Transcription of Inflammatory Cytokines in Virologically Suppressed, HIV-Infected Womenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of the International AIDS Societyen_US
dash.depositing.authorMacLeod, Iain James
dc.date.available2013-04-25T18:47:30Z
dc.identifier.doi10.7448/IAS.15.2.17393*
dash.contributor.affiliatedMacLeod, Iain
dash.contributor.affiliatedShapiro, Roger
dash.contributor.affiliatedRowley, Christopher
dash.contributor.affiliatedOgwu, Anthony
dash.contributor.affiliatedMakhema, Joseph
dash.contributor.affiliatedEssex, Myron
dash.contributor.affiliatedLockman, Shahin


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