Identification of Cytolytic CD161\(^−\)CD56\(^+\) Regulatory CD8 T Cells in Human Peripheral Blood

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Identification of Cytolytic CD161\(^−\)CD56\(^+\) Regulatory CD8 T Cells in Human Peripheral Blood

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Title: Identification of Cytolytic CD161\(^−\)CD56\(^+\) Regulatory CD8 T Cells in Human Peripheral Blood
Author: Hu, Dan; Weiner, Howard L.; Ritz, Jerome

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Citation: Hu, Dan, Howard L. Weiner, and Jerome Ritz. 2013. Identification of cytolytic CD161\(^−\)CD56\(^+\) regulatory CD8 cells in human peripheral blood. PLoS ONE 8(3): e59545.
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Abstract: We previously developed methods for establishing CD8 regulatory T cell (Treg) clones from normal human peripheral blood and demonstrated that these clones were capable of killing T cell receptor (TCR)-activated autologous CD4 T cells. Based on phenotypic and functional characterization of the CD8 Treg clones, we have identified a corresponding population of endogenous CD8 Treg in normal human peripheral blood. These cells appear morphologically as large lymphocytes with abundant cytoplasm and have the following unique phenotype: CD3\(^+\)CD8\(^+\)CD161\(^−\)CD56\(^+\). The majority of CD8 Treg express CD45RA and CD62L with low or negative expression of CD45RO, CD25, CD27, CD28 and CCR7. The expression of CD94 and NKG2a on CD8 Treg was elevated compared to conventional CD8 T cells. Following in vitro activation, this T cell subset is capable of killing TCR-activated CD4 T cells. These studies identify an endogenous CD8 Treg population in humans and it will now be possible to characterize these cells in a variety of clinical conditions.
Published Version: doi:10.1371/journal.pone.0059545
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602421/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10591654
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