Computational Knowledge Integration in Biopharmaceutical Research

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Computational Knowledge Integration in Biopharmaceutical Research

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dc.contributor.author Ficenec, David
dc.contributor.author Osborne, Mark
dc.contributor.author Pradines, Joel
dc.contributor.author Richards, Dan
dc.contributor.author Felciano, Ramon
dc.contributor.author Cho, Raymond
dc.contributor.author Chen, Richard
dc.contributor.author Liefeld, Ted
dc.contributor.author Owen, James
dc.contributor.author Ruttenberg, Alan
dc.contributor.author Reich, Christian
dc.contributor.author Clark, Timothy William
dc.date.accessioned 2013-04-30T13:33:32Z
dc.date.issued 2003
dc.identifier Quick submit: 2013-04-04T23:37:26-04:00
dc.identifier.citation Ficenec, David, Mark Osborne, Joel Pradines, Dan Richards, Ramon Felciano, Raymond J. Cho, Richard O. Chen, et al. 2003. Computational knowledge integration in biopharmaceutical research. Briefings in Bioinformatics 4(3): 260–278. en_US
dc.identifier.issn 1467-5463 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:10591706
dc.description.abstract An initiative to increase biopharmaceutical research productivity by capturing, sharing and computationally integrating proprietary scientific discoveries with public knowledge is described. This initiative involves both organisational process change and multiple interoperating software systems. The software components rely on mutually supporting integration techniques. These include a richly structured ontology, statistical analysis of experimental data against stored conclusions, natural language processing of public literature, secure document repositories with lightweight metadata, web services integration, enterprise web portals and relational databases. This approach has already begun to increase scientific productivity in our enterprise by creating an organisational memory (OM) of internal research findings, accessible on the web. Through bringing together these components it has also been possible to construct a very large and expanding repository of biological pathway information linked to this repository of findings which is extremely useful in analysis of DNA microarray data. This repository, in turn, enables our research paradigm to be shifted towards more comprehensive systems-based understandings of drug action. en_US
dc.language.iso en_US en_US
dc.relation.isversionof http://bib.oxfordjournals.org/content/4/3/260.short en_US
dash.license LAA
dc.title Computational Knowledge Integration in Biopharmaceutical Research en_US
dc.type Journal Article en_US
dc.date.updated 2013-04-05T03:37:35Z
dc.description.version Version of Record en_US
dc.rights.holder Ficenec D, Osborne M, Pradines J, Richards D, Felciano R, Cho RJ, Liefeld T, Owen JJ, Ruttenberg A, Reich C, Horvath J, Clark T
dc.relation.journal Briefings in Bioinformatics en_US
dash.depositing.author Clark, Timothy William
dc.date.available 2013-04-30T13:33:32Z

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