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dc.contributor.authorFicenec, David
dc.contributor.authorOsborne, Mark
dc.contributor.authorPradines, Joel
dc.contributor.authorRichards, Dan
dc.contributor.authorFelciano, Ramon
dc.contributor.authorCho, Raymond
dc.contributor.authorChen, Richard
dc.contributor.authorLiefeld, Ted
dc.contributor.authorOwen, James
dc.contributor.authorRuttenberg, Alan
dc.contributor.authorReich, Christian
dc.contributor.authorClark, Timothy William
dc.date.accessioned2013-04-30T13:33:32Z
dc.date.issued2003
dc.identifierQuick submit: 2013-04-04T23:37:26-04:00
dc.identifier.citationFicenec, David, Mark Osborne, Joel Pradines, Dan Richards, Ramon Felciano, Raymond J. Cho, Richard O. Chen, et al. 2003. Computational knowledge integration in biopharmaceutical research. Briefings in Bioinformatics 4(3): 260–278.en_US
dc.identifier.issn1467-5463en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10591706
dc.description.abstractAn initiative to increase biopharmaceutical research productivity by capturing, sharing and computationally integrating proprietary scientific discoveries with public knowledge is described. This initiative involves both organisational process change and multiple interoperating software systems. The software components rely on mutually supporting integration techniques. These include a richly structured ontology, statistical analysis of experimental data against stored conclusions, natural language processing of public literature, secure document repositories with lightweight metadata, web services integration, enterprise web portals and relational databases. This approach has already begun to increase scientific productivity in our enterprise by creating an organisational memory (OM) of internal research findings, accessible on the web. Through bringing together these components it has also been possible to construct a very large and expanding repository of biological pathway information linked to this repository of findings which is extremely useful in analysis of DNA microarray data. This repository, in turn, enables our research paradigm to be shifted towards more comprehensive systems-based understandings of drug action.en_US
dc.language.isoen_USen_US
dc.relation.isversionofhttp://bib.oxfordjournals.org/content/4/3/260.shorten_US
dash.licenseLAA
dc.titleComputational Knowledge Integration in Biopharmaceutical Researchen_US
dc.typeJournal Articleen_US
dc.date.updated2013-04-05T03:37:35Z
dc.description.versionVersion of Recorden_US
dc.rights.holderFicenec D, Osborne M, Pradines J, Richards D, Felciano R, Cho RJ, Liefeld T, Owen JJ, Ruttenberg A, Reich C, Horvath J, Clark T
dc.relation.journalBriefings in Bioinformaticsen_US
dash.depositing.authorClark, Timothy William
dc.date.available2013-04-30T13:33:32Z
dash.authorsorderedfalse
dash.contributor.affiliatedClark, Tim


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