T granules in human platelets function in TLR9 organization and signaling

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T granules in human platelets function in TLR9 organization and signaling

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Title: T granules in human platelets function in TLR9 organization and signaling
Author: Thon, Jonathan N.; Peters, Christopher G.; Machlus, Kellie R.; Aslam, Rukhsana; Rowley, Jesse; Macleod, Hannah; Devine, Matthew T.; Fuchs, Tobias A; Weyrich, Andrew S.; Semple, John W.; Flaumenhaft, Robert C.; Italiano, Joseph E.

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Citation: Thon, Jonathan N., Christopher G. Peters, Kellie R. Machlus, Rukhsana Aslam, Jesse Rowley, Hannah Macleod, Matthew T. Devine, et al. 2012. T granules in human platelets function in tlr9 organization and signaling. The Journal of Cell Biology 198(4): 561-574.
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Abstract: Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link the innate and adaptive immune responses during infectious inflammation and atherosclerotic vascular disease. In this paper, we show that the TLR9 transcript is specifically up-regulated during pro-PLT production and is distributed to a novel electron-dense tubular system-related compartment we have named the T granule. TLR9 colocalizes with protein disulfide isomerase and is associated with either VAMP 7 or VAMP 8, which regulates its distribution in PLTs on contact activation (spreading). Preincubation of PLTs with type IV collagen specifically increased TLR9 and CD62P surface expression and augmented oligodeoxynucleotide (ODN) sequestration and PLT clumping upon addition of bacterial/viral ODNs. Collectively, this paper (a) tracks TLR9 to a new intracellular compartment in PLTs and (b) describes a novel mechanism of TLR9 organization and signaling in human PLTs.
Published Version: doi:10.1083/jcb.201111136
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514030/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10594370
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