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dc.contributor.authorOhsumi, Toshiro K.
dc.contributor.authorBorowsky, Mark L
dc.date.accessioned2013-05-02T13:05:57Z
dc.date.issued2012
dc.identifier.citationOhsumi, Toshiro K., and Mark L. Borowsky. 2012. MolBioLib: A C++11 framework for rapid development and deployment of bioinformatics tasks. Bioinformatics 28(19): 2412-2416.en_US
dc.identifier.issn1367-4803en_US
dc.identifier.issn1460-2059en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10609729
dc.description.abstractSummary: We developed MolBioLib to address the need for adaptable next-generation sequencing analysis tools. The result is a compact, portable and extensively tested C++11 software framework and set of applications tailored to the demands of next-generation sequencing data and applicable to many other applications. MolBioLib is designed to work with common file formats and data types used both in genomic analysis and general data analysis. A central relational-database-like Table class is a flexible and powerful object to intuitively represent and work with a wide variety of tabular datasets, ranging from alignment data to annotations. MolBioLib has been used to identify causative single-nucleotide polymorphisms in whole genome sequencing, detect balanced chromosomal rearrangements and compute enrichment of messenger RNAs (mRNAs) on microtubules, typically requiring applications of under 200 lines of code. MolBioLib includes programs to perform a wide variety of analysis tasks, such as computing read coverage, annotating genomic intervals and novel peak calling with a wavelet algorithm. Although MolBioLib was designed primarily for bioinformatics purposes, much of its functionality is applicable to a wide range of problems. Complete documentation and an extensive automated test suite are provided.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/bioinformatics/bts458en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463126/pdf/en_US
dash.licenseLAA
dc.subjectGenome Analysisen_US
dc.titleMolBioLib: A C++11 Framework for Rapid Development and Deployment of Bioinformatics Tasksen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBioinformaticsen_US
dash.depositing.authorBorowsky, Mark L
dc.date.available2013-05-02T13:05:57Z
dc.identifier.doi10.1093/bioinformatics/bts458*
dash.contributor.affiliatedBorowsky, Mark L


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