Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model
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Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model
| Title: | Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model |
| Author: |
Martin, Corey S; Moriyama, Akemi; Zon, Leonard Ira
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Martin, Corey S., Akemi Moriyama, and Leonard Ira Zon. 2011. Hematopoietic stem cells, hematopoiesis and disease: Lessons from the zebrafish model. Genome Medicine 3(12): 83. |
| Full Text & Related Files: |
3334548.pdf (2.354Mb; PDF) 
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| Abstract: | The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by producing transparent, externally fertilized embryos. Embryonic zebrafish are easily visualized and manipulated through microinjection, chemical treatment, and mutagenesis. These procedures have contributed to large-scale chemical, suppressor, and genetic screens to identify hematopoietic gene mutations. Genomic conservation and local synteny between the human and zebrafish genomes make genome-scale and epigenetic analysis of these mutations (by microarray, chromatin immunoprecipitation sequencing, and RNA sequencing procedures) powerful methods for translational research and medical discovery. In addition, large-scale screening techniques have resulted in the identification of several small molecules capable of rescuing hematopoietic defects and inhibiting disease. Here, we discuss the contributions of the zebrafish model to the understanding of hematopoiesis, hematopoietic stem cell development, and disease-related discovery. We also highlight the recent discovery of small molecules with clinical promise, such as dimethyl prostaglandin E2, 3F8, and thiazole-carboxamide 10A. |
| Published Version: | doi:10.1186/gm299 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334548/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10609733 |
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