Detectable Clonal Mosaicism from Birth to Old Age and its Relationship to Cancer

DSpace/Manakin Repository

Detectable Clonal Mosaicism from Birth to Old Age and its Relationship to Cancer

Citable link to this page

 

 
Title: Detectable Clonal Mosaicism from Birth to Old Age and its Relationship to Cancer
Author: Laurie, Cathy C.; Laurie, Cecelia A.; Doheny, Kimberly F.; Zelnick, Leila R.; McHugh, Caitlin P.; Ling, Hua; Hetrick, Kurt N.; Amos, Chris; Wei, Qingyi; Wang, Li-e; Hansel, Nadia N.; Mathias, Rasika; Daley, Denise; Beaty, Terri H.; Scott, Alan F.; Ruczinski, Ingo; Scharpf, Rob B.; Bierut, Laura J.; Hartz, Sarah M.; Landi, Maria Teresa; Freedman, Neal D.; Goldin, Lynn R.; Ginsburg, David; Desch, Karl C.; Strom, Sara S.; Blot, William J.; Ingles, Sue A.; Chanock, Stephen J.; Berndt, Sonja I.; Le Marchand, Loic; Monroe, Kristine R; Heit, John A.; de Andrade, Mariza; Armasu, Sebastian M.; Regnier, Cynthia; Lowe, William L.; Marazita, Mary L.; Feingold, Eleanor; Murray, Jeffrey C.; Melbye, Mads; Feenstra, Bjarke; Jarvik, Gail P.; McDavid, Andrew N.; Seshan, Venkatraman E.; Mirel, Daniel B.; Crenshaw, Andrew; Sharopova, Nataliya; Wise, Anastasia; Shen, Jess; Crosslin, David R.; Zheng, Xiuwen; Udren, Jenna I; Bennett, Siiri; Gogarten, Stephanie M.; Conomos, Matthew P.; Heagerty, Patrick; Manolio, Teri; Haiman, Christopher A.; Caporaso, Neil; Weir, Bruce S.; Rice, Kenneth; Kang, Jae Hee; Pugh, Elizabeth W.; Lee, Jeffrey E.; Barnes, Kathleen C.; Li, Jun; Signorello, Lisa B; Henderson, Brian E.; Hayes, M. Geoffrey; Wiggs, Janey Lee; Levine, David M.; Nelson, Sarah C.; Pasquale, Louis

Note: Order does not necessarily reflect citation order of authors.

Citation: Laurie, Cathy C., Cecelia A. Laurie, Kenneth Rice, Kimberly F. Doheny, Leila R. Zelnick, Caitlin P. McHugh, Hua Ling, et al. 2012. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nature Genetics 44(6): 642-650.
Full Text & Related Files:
Abstract: Clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) was detected using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells (>5–10%) with the same abnormal karyotype (presumably of clonal origin) in the presence of normal cells. The frequency of detectable clonal mosaicism in peripheral blood is low (<0.5%) from birth until 50 years of age, after which it rises rapidly to 2–3% in the elderly. Many of the mosaic anomalies are characteristic of those found in hematological cancers and identify common deleted regions that pinpoint the locations of genes previously associated with hematological cancers. Although only 3% of subjects with detectable clonal mosaicism had any record of hematological cancer prior to DNA sampling, those without a prior diagnosis have an estimated 10-fold higher risk of a subsequent hematological cancer (95% confidence interval = 6–18).
Published Version: doi:10.1038/ng.2271
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366033/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10610368
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters