PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells

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PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells

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Title: PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells
Author: Feuerer, Markus; Kamei, Nozomu; Cipolletta, Daniela; Li, Amy; Lee, Jongsoon; Shoelson, Steven E.; Benoist, Christophe O.; Mathis, Diane J.

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Citation: Cipolletta, Daniela, Markus Feuerer, Amy Li, Nozomu Kamei, Jongsoon Lee, Steven E. Shoelson, Christophe O. Benoist, and Diane J. Mathis. 2012. PPARγ is a major driver of the accumulation and phenotype of adipose-tissue \(T_{reg}\) cells. Nature 486(7404): 549-553.
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Abstract: Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the accumulation and activation of leukocytes in visceral adipose tissue (VAT) and ultimately other tissues, leading to metabolic abnormalities such as insulin resistance, type-2 diabetes and fatty-liver disease. Although invasion of VAT by pro-inflammatory macrophages is considered to be a key event driving adipose-tissue inflammation and insulin resistance, little is known about the roles of other immune system cell types in these processes. A unique population of VAT-resident regulatory T \((T_{reg})\) cells was recently implicated in control of the inflammatory state of adipose tissue and, thereby, insulin sensitivity. Here we identify peroxisome proliferator-activated receptor (PPAR)-γ, the ‘master regulator’ of adipocyte differentiation, as a crucial molecular orchestrator of VAT \(T_{reg}\) cell accumulation, phenotype and function. Unexpectedly, PPAR-γ expression by VAT \(T_{reg}\) cells was necessary for complete restoration of insulin sensitivity in obese mice by the thiazolidinedione drug pioglitazone. These findings suggest a previously unknown cellular mechanism for this important class of thiazolidinedione drugs, and provide proof-of-principle that discrete populations of \(T_{reg}\) cells with unique functions can be precisely targeted to therapeutic ends.
Published Version: doi:10.1038/nature11132
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387339/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10610379
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