Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers

DSpace/Manakin Repository

Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers

Citable link to this page

 

 
Title: Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers
Author: Martinot, Amanda Jezek ORCID  0000-0001-6237-6191 ; Meythaler, Mareike; Pozzi, Lu-Ann; Dalecki Boisvert, Karen; Knight, Heather Lynn; Walsh, Dennis; Westmoreland, Susan V.; Anderson, Daniel C.; Kaur, Amitinder; O’Neil, Shawn P.

Note: Order does not necessarily reflect citation order of authors.

Citation: Martinot, Amanda J., Mareike Meythaler, Lu-Ann Pozzi, Karen Dalecki Boisvert, Heather Knight, Dennis Walsh, Susan Westmoreland, Daniel C. Anderson, Amitinder Kaur, and Shawn P. O’Neil. 2013. Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. PLoS ONE 8(3): e57785.
Full Text & Related Files:
Abstract: Lymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts. To investigate factors contributing to this difference, we compared germinal center development and SIV RNA distribution in peripheral lymph nodes during primary SIV infection of the natural host sooty mangabey and the non-natural host pig-tailed macaque. Although SIV-infected cells were detected in the lymph node of both species at two weeks post infection, they were confined to the lymph node paracortex in immune-competent mangabeys but were seen in both the paracortex and the germinal center of SIV-infected macaques. By six weeks post infection, SIV-infected cells were no longer detected in the lymph node of sooty mangabeys. The difference in localization and rate of disappearance of SIV-infected cells between the two species was associated with trapping of cell-free virus on follicular dendritic cells and higher numbers of germinal center CD4+ T lymphocytes in macaques post SIV infection. Our data suggests that fundamental differences in the germinal center microenvironment prevent productive SIV infection within the lymph node germinal centers of natural hosts contributing to sustained immune competency.
Published Version: doi:10.1371/journal.pone.0057785
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589484/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10611684
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters