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dc.contributor.authorMartinot, Amanda Jezek
dc.contributor.authorMeythaler, Mareike
dc.contributor.authorPozzi, Lu-Ann
dc.contributor.authorDalecki Boisvert, Karen
dc.contributor.authorKnight, Heather Lynn
dc.contributor.authorWalsh, Dennis
dc.contributor.authorWestmoreland, Susan V.
dc.contributor.authorAnderson, Daniel C.
dc.contributor.authorKaur, Amitinder
dc.contributor.authorO’Neil, Shawn P.
dc.date.accessioned2013-05-07T14:56:23Z
dc.date.issued2013
dc.identifier.citationMartinot, Amanda J., Mareike Meythaler, Lu-Ann Pozzi, Karen Dalecki Boisvert, Heather Knight, Dennis Walsh, Susan Westmoreland, Daniel C. Anderson, Amitinder Kaur, and Shawn P. O’Neil. 2013. Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. PLoS ONE 8(3): e57785.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10611684
dc.description.abstractLymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts. To investigate factors contributing to this difference, we compared germinal center development and SIV RNA distribution in peripheral lymph nodes during primary SIV infection of the natural host sooty mangabey and the non-natural host pig-tailed macaque. Although SIV-infected cells were detected in the lymph node of both species at two weeks post infection, they were confined to the lymph node paracortex in immune-competent mangabeys but were seen in both the paracortex and the germinal center of SIV-infected macaques. By six weeks post infection, SIV-infected cells were no longer detected in the lymph node of sooty mangabeys. The difference in localization and rate of disappearance of SIV-infected cells between the two species was associated with trapping of cell-free virus on follicular dendritic cells and higher numbers of germinal center CD4+ T lymphocytes in macaques post SIV infection. Our data suggests that fundamental differences in the germinal center microenvironment prevent productive SIV infection within the lymph node germinal centers of natural hosts contributing to sustained immune competency.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0057785en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589484/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectImmune Physiologyen_US
dc.subjectLymphatic Systemen_US
dc.subjectImmunologyen_US
dc.subjectImmune Systemen_US
dc.subjectLymphoid Organsen_US
dc.subjectImmunopathologyen_US
dc.subjectMicrobiologyen_US
dc.subjectVirologyen_US
dc.subjectAnimal Models of Infectionen_US
dc.subjectMedicineen_US
dc.subjectInfectious Diseasesen_US
dc.subjectViral Diseasesen_US
dc.subjectHIVen_US
dc.subjectRetrovirology and HIV immunopathogenesisen_US
dc.titleAcute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorKaur, Amitinder
dc.date.available2013-05-07T14:56:23Z
dc.identifier.doi10.1371/journal.pone.0057785*
dash.identifier.orcid0000-0001-6237-6191*
dash.contributor.affiliatedKnight, Heather Lynn
dash.contributor.affiliatedMartinot, Amanda
dash.contributor.affiliatedKaur, Amitinder
dash.contributor.affiliatedWestmoreland, Susan V.
dc.identifier.orcid0000-0001-6237-6191


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