Effectiveness of the Viet Nam Produced, Mouse BrainDerived, Inactivated Japanese Encephalitis Vaccine in Northern Viet Nam

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Effectiveness of the Viet Nam Produced, Mouse BrainDerived, Inactivated Japanese Encephalitis Vaccine in Northern Viet Nam

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Title: Effectiveness of the Viet Nam Produced, Mouse BrainDerived, Inactivated Japanese Encephalitis Vaccine in Northern Viet Nam
Author: Marks, Florian; Nguyen, Thi Thu Yen; Tran, Nhu Duong; Nguyen, Minh Hong; Vu, Hai Ha; Meyer, Christian G.; You, Young Ae; Konings, Frank; Liu, Wei; Wierzba, Thomas F.; Xu, Zhi-Yi

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Citation: Marks, Florian, Thi Thu Yen Nguyen, Nhu Duong Tran, Minh Hong Nguyen, Hai Ha Vu, Christian G. Meyer, Young Ae You, Frank Konings, Wei Liu, Thomas F. Wierzba, and Zhi-Yi Xu. 2012. Effectiveness of the Viet Nam produced, mouse brain derived, inactivated Japanese encephalitis vaccine in northern Viet Nam. PLoS Neglected Tropical Diseases 6(12): e1952.
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Abstract: Background: Japanese encephalitis (JE) is a flaviviral disease of public health concern in many parts of Asia. JE often occurs in large epidemics, has a high case-fatality ratio and, among survivors, frequently causes persistent neurological sequelae and mental disabilities. In 1997, the Vietnamese government initiated immunization campaigns targeting all children aged 1–5 years. Three doses of a locally-produced, mouse brain-derived, inactivated JE vaccine (MBV) were given. This study aims at evaluating the effectiveness of Viet Nam’s MBV. Methodology: A matched case-control study was conducted in Northern Viet Nam. Cases were identified through an ongoing hospital-based surveillance. Each case was matched to four healthy controls for age, gender, and neighborhood. The vaccination history was ascertained through JE immunization logbooks maintained at local health centers. Principal Findings: Thirty cases and 120 controls were enrolled. The effectiveness of the JE vaccine was 92.9% [95% CI: 66.6–98.5]. Confounding effects of other risk variables were not observed. Conclusions: Our results strongly suggest that the locally-produced JE-MBV given to 1–5 years old Vietnamese children was efficacious.
Published Version: doi:10.1371/journal.pntd.0001952
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521705/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10611731
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